| Type | Description |
|---|---|
| Definition | phospholipase C beta 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:14:00 | Knockdown of PLCB2 expression reduces melanoma cell viability and promotes melanoma cell apoptosis by altering Ras/Raf/MAPK signals. | 31746389 |
| 2019-07-06 10:50:00 | High PLCB2 expression is associated with breast cancer. | 30582225 |
| 2018-05-05 11:40:00 | this work adds substantial information about the role of PLC-beta2 in invasive breast tumors, demonstrating that its up-regulation in cells with a basal-B triple-negative phenotype is sufficient to down-modulate the expression of surface antigens crucial for malignancy and to reduce the number of cells with a stem-like phenotype. | 28870198 |
| 2017-09-09 10:50:00 | Hypoxia modulates the expression of PLC-beta-2 in breast tumor cells in a phenotype-related manner, since a decrease of the protein was observed in the BT-474 and MCF7 cell lines while an increase was revealed in MDA-MB-231 cells as a consequence of low oxygen availability. | 26785288 |
| 2016-06-11 10:57:00 | Gnb isoforms control a signaling pathway comprising Rac1, Plcbeta2, and Plcbeta3 leading to LFA-1 activation and neutrophil arrest in vivo | 26468229 |
| Type | IDs |
|---|---|
| Synonymous | PLC-beta-2 |
| Gene |
UniProtKB-ID:
PLCB2_HUMAN,
Q9BVT6_HUMAN,
Q59F77_HUMAN
UniprotKB:
Q00722,
Q9BVT6,
Q59F77
UniParc:
UPI00004F6D61,
UPI0000131A91,
UPI000006E017,
UPI000192C3F5,
UPI0000D79B75
EMBL:
M95678,
AK291657,
AB209583,
AC020658,
BC136467,
CH471125,
BT006905,
BC009009,
BC000939
Ensembl:
ENSG00000137841
KO:
hsa:5330
|
| Nucleutide sequences |
EMBL-CDS:
BAF84346.1,
AAI36468.1,
AAA36453.1,
AAP35551.1,
AAH09009.1,
EAW92402.1,
AAH00939.1,
BAD92820.1
Gene_ORFName:
hCG_38956
Ensembl_TRS:
ENST00000456256,
ENST00000260402,
ENST00000557821,
ENST00000543785
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000260402,
ENSP00000411991,
ENSP00000453975,
ENSP00000444652
RefSeq:
XP_016877803.1,
XP_024305720.1,
XP_024305717.1,
NP_001271226.1,
XP_016877806.1,
XP_024305718.1,
XP_016877808.1,
XP_024305719.1,
XP_024305716.1,
NP_001271227.1,
NP_004564.2,
NP_001271228.1
|
| Others |
UniRef100:
UniRef100_Q59F77,
UniRef100_Q00722,
UniRef100_Q9BVT6
UniRef90:
UniRef90_A0A2I3MLF4,
UniRef90_Q59F77,
UniRef90_Q00722
UniRef50:
UniRef50_A0A672QF58,
UniRef50_A0A2I3MLF4,
UniRef50_Q00722
UniGene:
Hs.355888
CCDS:
CCDS61592.1,
CCDS42020.1,
CCDS61591.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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