| Type | Description |
|---|---|
| Definition | phosphogluconate dehydrogenase |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:44:00 | HIF-1alpha regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors. | 32719331 |
| 2020-10-10 13:03:00 | 6PGD Upregulation is Associated with Chemo- and Immuno-Resistance of Renal Cell Carcinoma via AMPK Signaling-Dependent NADPH-Mediated Metabolic Reprograming. | 32829780 |
| 2019-07-27 11:07:00 | 6-phosphogluconate dehydrogenase (6PGD) is aberrantly upregulated and activated in cervical cancer cells and patient tissues compared to normal counterparts. 6PGD inhibition decreases growth and migration, and enhances chemosensitivity in cervical cancer. Inhibition of 6PGD activates AMP-activated protein kinase and decreases rhoA GTP-binding protein and rac1 GTP-binding protein activities. | 30182212 |
| 2018-04-14 10:33:00 | identified that 6-phosphogluconate dehydrogenase (6PGD) is critically involved in the development of anaplastic thyroid cancer (ATC) resistance to doxorubicin. 6PGD inhibition disrupts metabolic reprogramming in doxorubicin-resistant ATC cells. | 29534964 |
| 2016-03-19 10:16:00 | Studies indicate link between the 6-phosphogluconate dehydrogenase, oxidative pentose phosphate pathway (PPP) and lipogenesis through Ru-5-P-dependent inhibition of serine/threonine protein kinase LKB1-AMPK signalling. | 26479318 |
| Type | IDs |
|---|---|
| Synonymous | 6PGD |
| Gene |
UniProtKB-ID:
6PGD_HUMAN,
B4E2U0_HUMAN
UniprotKB:
P52209,
B4E2U0
UniParc:
UPI0000205F06,
UPI0000169DB9,
UPI00017A86DB
EMBL:
AK290404,
BC000368,
U30255,
AK304423,
AK298830,
CH471130,
AL139424
Ensembl:
ENSG00000142657
KO:
hsa:5226
|
| Nucleutide sequences |
EMBL-CDS:
AAA75302.1,
EAW71648.1,
AAH00368.1,
BAG60960.1,
BAF83093.1,
BAG65252.1
Ensembl_TRS:
ENST00000270776
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000270776
RefSeq:
NP_002622.2,
NP_001291381.1,
NP_001291380.1
|
| Others |
UniRef100:
UniRef100_B4E2U0,
UniRef100_P52209
UniRef90:
UniRef90_P52209
UniRef50:
UniRef50_P52209
UniGene:
Hs.464071
CCDS:
CCDS113.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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