| Type | Description |
|---|---|
| Definition | ubiquitin interaction motif containing 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 10:27:00 | BRCA1 poly-ADP ribosylation (PARsylation) and the presence of BRCA1-bound RAP80 are critical for the normal interaction of BRCA1 with some of its partners (e.g., CtIP and BACH1). | 31932421 |
| 2020-01-18 11:48:00 | Here we show that in the BRCA1-A complex structure, ABRAXAS integrates the DNA repair protein RAP80 and provides a high-affinity binding site that sequesters the tumor suppressor BRCA1 away from the break site. In the BRISC structure, ABRO1 binds SHMT2alpha, a metabolic enzyme enabling cancer growth in hypoxic environments, which we find prevents BRCC36 from binding and cleaving ubiquitin chains | 31253574 |
| 2019-08-03 13:42:00 | RAP80 positively regulated the stability of USP13 to promote cell proliferation of esophageal cancer cells. | 29396516 |
| 2018-12-22 10:28:00 | RAP80-BRCA1 complex foci formation is regulated by USP13.USP13 interacts with and deubiquitinates RAP80.RAP80 role in the DNA damage response. | 28569838 |
| 2017-10-28 12:10:00 | The RAP80 deficiency reduces the protein level of p32 and p32 dependent mitochondrial translating proteins such as Rieske and COX1. | 28842250 |
| Type | IDs |
|---|---|
| Synonymous | RAP80, X2HRIP110 |
| Gene |
UniProtKB-ID:
UIMC1_HUMAN,
A0A024R7R0_HUMAN
UniprotKB:
Q96RL1,
A0A024R7R0
UniParc:
UPI0000071EB4,
UPI000006D9B5,
UPI00004CE21E,
UPI00001A9954,
UPI00017A88F5
EMBL:
AF349313,
AF113538,
BC032561,
AF284749,
BX537376,
AF284753,
CH471195,
AK023044,
AK304794,
BC006078,
AC027318
Ensembl:
ENSG00000087206
KO:
hsa:51720
|
| Nucleutide sequences |
EMBL-CDS:
BAG51153.1,
AAG59851.1,
AAH06078.1,
BAG65544.1,
AAK61871.1,
CAD97618.1,
AAF14875.1,
AAG59855.1,
AAH32561.1,
EAW85043.1,
EAW85044.1
Gene_ORFName:
hCG_41582
Ensembl_TRS:
ENST00000506128,
ENST00000511320,
ENST00000510698,
ENST00000377227
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000421926,
ENSP00000366434,
ENSP00000423717,
ENSP00000427480
RefSeq:
NP_057374.3,
XP_006714937.1,
XP_016865063.1,
XP_005265987.1,
XP_016865067.1,
XP_006714934.1,
XP_011532872.1,
XP_016865065.1,
NP_001304890.1,
NP_001186226.1,
XP_005265992.1,
XP_005265990.1,
XP_016865064.1,
XP_016865068.1,
XP_005265993.1,
XP_005265989.1,
XP_011532870.1,
XP_016865066.1,
XP_005265991.1,
NP_001186227.1
|
| Others |
UniRef100:
UniRef100_Q96RL1
UniRef90:
UniRef90_Q96RL1
UniRef50:
UniRef50_Q96RL1
UniGene:
Hs.232721
CCDS:
CCDS83050.1,
CCDS4408.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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