| Type | Description |
|---|---|
| Definition | SUFU negative regulator of hedgehog signaling |
| Date | Results | Publications |
|---|---|---|
| 2020-09-12 16:00:00 | LIFR-AS1 modulates Sufu to inhibit cell proliferation and migration by miR-197-3p in breast cancer. | 31127025 |
| 2019-12-07 11:37:00 | The Twist1-regulated miR-214 promotes the activation of Hepatic stellate cells through targeting Sufu involved in the Hedgehog pathway and participates in the development of hepatic fibrosis. Hence, the knockdown of miR-214 expression may be a promising therapeutic strategy for liver fibrosis. | 29915227 |
| 2019-10-05 11:07:00 | Germline SUFU mutations are associated with medulloblastoma. | 29186568 |
| 2019-08-03 12:25:00 | establishes the dual role of SUFU inSonic Hedgehog medulloblastoma (MB) and provides mechanistic insights into transcriptional regulation underlying Gli2-mediated SHH MB tumorigenesis | 30554998 |
| 2019-04-27 11:49:00 | MiR-423-5p enriched exosomes could be internalized into gastric cancer cells, which enhanced cell proliferation and migration both in vitro and in vivo. Mechanistically, miR-423-5p inhibited the expression of suppressor of fused protein (SUFU) to enhance the proliferation and migration of gastric cancer cells. The expression levels of SUFU were significantly decreased in gastric cancer cells and the tumor tissues. | 29749061 |
| Type | IDs |
|---|---|
| Synonymous | JBTS32, PRO1280, SUFUH, SUFUXL |
| Gene |
UniProtKB-ID:
SUFU_HUMAN,
A0A223LX15_HUMAN
UniprotKB:
Q9UMX1,
A0A223LX15
UniParc:
UPI0005D0328F,
UPI000004C5FF,
UPI000006D11C,
UPI0000073C79
EMBL:
AY081823,
AF172319,
AY358550,
AY081820,
AL391121,
AF175770,
AY081828,
AY081824,
AY081822,
AY081821,
AL121928,
AY081827,
AF222345,
AL137465,
AF159447,
BC013291,
AY081819,
AF144231,
AL157386,
KX708747,
AY081818,
AY081829,
AY081825,
AY081826
Ensembl:
ENSG00000107882
KO:
hsa:51684
|
| Nucleutide sequences |
EMBL-CDS:
AAH13291.1,
AAF23893.1,
CAB70752.1,
AAF35866.1,
AAD51655.1,
AAD50501.1,
AAF23890.1,
AAM08947.1,
AAQ88914.1,
ASU09552.1
Gene_ORFName:
UNQ650/PRO1280
Ensembl_TRS:
ENST00000423559,
ENST00000369899,
ENST00000369902
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000358918,
ENSP00000411597,
ENSP00000358915
RefSeq:
XP_011538160.1,
XP_011538163.1,
NP_057253.2,
NP_001171604.1,
XP_011538165.1,
XP_011538166.1,
XP_016871812.1,
XP_011538162.1
|
| Others |
UniRef100:
UniRef100_A0A223LX15,
UniRef100_Q9UMX1
UniRef90:
UniRef90_Q9UMX1,
UniRef90_A0A223LX15
UniRef50:
UniRef50_Q9UMX1,
UniRef50_W5NTI5
UniGene:
Hs.404089
CCDS:
CCDS7537.1,
CCDS53571.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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