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51669 SARAF

51669

SARAF

store-operated calcium entry associated regulatory factor

protein-coding

Homo sapiens

基因描述

Type Description
Definition store-operated calcium entry associated regulatory factor

研究结论

Date Results Publications
2021-04-13 10:12:00 Temporal modulation of calcium sensing in hematopoietic stem cells is crucial for proper stem cell expansion and engraftment. 32394484
2020-08-15 19:07:00 Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca(2+) entry-mediated turnover of focal adhesions. 32079527
2020-07-25 13:02:00 Y316F mutation altered the pattern of interaction between STIM1 and under resting conditions and upon Ca(2+) store depletion. Expression of the STIM1 Y316F mutant enhanced slow Ca(2+)-dependent inactivation (SCDI) as compared to STIM1 WT, an effect that was abolished by duanyu1800F knockdown. 30975919
2020-06-20 10:33:00 Described is the X-ray crystal structure of the luminal domain, This domain forms a novel 10-stranded beta-sandwich fold that includes a set of three conserved disulfide bonds, denoted the The structure reveals a domain-swapped dimer in which the last two beta-strands (beta9 and beta10) are exchanged forming a region denoted the luminal switch" that is essential for dimerization. 31082439
2020-01-04 12:10:00 Study shows that interacted with STIM1 to limit Ca2+ influx during physiological stimulation, but interaction of duanyu1800F with STIM1 was transient during pathological stimulation of acinar cells, resulting in sustained, toxic Ca2+ influx. Transgenic expression of duanyu1800F in mouse pancreatic acini reduced pathologic Ca2+ influx, prevented inflammation, and reduced tissue damage in mouse models of severe pancreatitis. 31493399

名称对应

Type IDs
Synonymous FOAP-7, HSPC035, TMEM66, XTP3
Gene
UniProtKB-ID: SARAF_HUMAN, B7Z307_HUMAN, A0A140VK59_HUMAN
UniprotKB: Q96BY9, B7Z307, A0A140VK59
UniParc: UPI000015F95E, UPI000020FF93, UPI0000035F61
EMBL: JQ348891, JQ348892, BC015012, AC044849, AK075340, AF100748, AB028926, AF490252, AF078855, HM005599, AY359104, AK222632, AK295360, AK315956, CH471080
Ensembl: ENSG00000133872
KO: hsa:51669
Nucleutide sequences
EMBL-CDS: EAW63472.1, BAB82465.1, AAD43012.1, AAD44487.1, BAD96352.1, BAH14327.1, AAO85460.1, AAH15012.1, EAW63471.1, AEZ06362.1, EAW63474.1, AEZ06361.1, AAQ89462.1, BAG52116.1, BAH12043.1, AEE61196.1
Gene_ORFName: PSEC0019, NPD003, HSPC035, UNQ1967/PRO4499
Ensembl_TRS: ENST00000256255, ENST00000545648
Protein sequencees
Ensembl_PRO: ENSP00000256255, ENSP00000441351
RefSeq: XP_016869057.1, NP_001271168.1, XP_016869059.1, XP_016869056.1, XP_016869058.1, NP_057211.4
Others
UniRef100: UniRef100_Q96BY9
UniRef90: UniRef90_Q96BY9
UniRef50: UniRef50_Q96BY9
UniGene: Hs.521487
CCDS: CCDS6074.1, CCDS64866.1

全选

研究热度
发表文献
研究结论
热点单位
排名 科研单位 文献
1

University of Extremadura

5
2

Weizmann Institute of Science

2
3

Helix Research Institute

2
4

National Institute of Dental and Craniofacial Research

2
5

Institute of Molecular Pathology Biomarkers

2
热点人员
排名 研究人员 文献
1

Juan A Rosado

7
2

Letizia Albarran

5
3

Gines M Salido

5
4

Jose J Lopez

4
5

Sumio Sugano

3
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