| Type | Description |
|---|---|
| Definition | store-operated calcium entry associated regulatory factor |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:12:00 | Temporal modulation of calcium sensing in hematopoietic stem cells is crucial for proper stem cell expansion and engraftment. | 32394484 |
| 2020-08-15 19:07:00 | Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca(2+) entry-mediated turnover of focal adhesions. | 32079527 |
| 2020-07-25 13:02:00 | Y316F mutation altered the pattern of interaction between STIM1 and under resting conditions and upon Ca(2+) store depletion. Expression of the STIM1 Y316F mutant enhanced slow Ca(2+)-dependent inactivation (SCDI) as compared to STIM1 WT, an effect that was abolished by duanyu1800F knockdown. | 30975919 |
| 2020-06-20 10:33:00 | Described is the X-ray crystal structure of the luminal domain, This domain forms a novel 10-stranded beta-sandwich fold that includes a set of three conserved disulfide bonds, denoted the The structure reveals a domain-swapped dimer in which the last two beta-strands (beta9 and beta10) are exchanged forming a region denoted the luminal switch" that is essential for dimerization. | 31082439 |
| 2020-01-04 12:10:00 | Study shows that interacted with STIM1 to limit Ca2+ influx during physiological stimulation, but interaction of duanyu1800F with STIM1 was transient during pathological stimulation of acinar cells, resulting in sustained, toxic Ca2+ influx. Transgenic expression of duanyu1800F in mouse pancreatic acini reduced pathologic Ca2+ influx, prevented inflammation, and reduced tissue damage in mouse models of severe pancreatitis. | 31493399 |
| Type | IDs |
|---|---|
| Synonymous | FOAP-7, HSPC035, TMEM66, XTP3 |
| Gene |
UniProtKB-ID:
SARAF_HUMAN,
B7Z307_HUMAN,
A0A140VK59_HUMAN
UniprotKB:
Q96BY9,
B7Z307,
A0A140VK59
UniParc:
UPI000015F95E,
UPI000020FF93,
UPI0000035F61
EMBL:
JQ348891,
JQ348892,
BC015012,
AC044849,
AK075340,
AF100748,
AB028926,
AF490252,
AF078855,
HM005599,
AY359104,
AK222632,
AK295360,
AK315956,
CH471080
Ensembl:
ENSG00000133872
KO:
hsa:51669
|
| Nucleutide sequences |
EMBL-CDS:
EAW63472.1,
BAB82465.1,
AAD43012.1,
AAD44487.1,
BAD96352.1,
BAH14327.1,
AAO85460.1,
AAH15012.1,
EAW63471.1,
AEZ06362.1,
EAW63474.1,
AEZ06361.1,
AAQ89462.1,
BAG52116.1,
BAH12043.1,
AEE61196.1
Gene_ORFName:
PSEC0019,
NPD003,
HSPC035,
UNQ1967/PRO4499
Ensembl_TRS:
ENST00000256255,
ENST00000545648
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000256255,
ENSP00000441351
RefSeq:
XP_016869057.1,
NP_001271168.1,
XP_016869059.1,
XP_016869056.1,
XP_016869058.1,
NP_057211.4
|
| Others |
UniRef100:
UniRef100_Q96BY9
UniRef90:
UniRef90_Q96BY9
UniRef50:
UniRef50_Q96BY9
UniGene:
Hs.521487
CCDS:
CCDS6074.1,
CCDS64866.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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