| Type | Description |
|---|---|
| Definition | family with sequence similarity 49 member B |
| Date | Results | Publications |
|---|---|---|
| 2020-01-25 14:08:00 | CYFIP related Rac1 interactor B (CYRI) binds to the small GTPase RAC1 through a conserved domain present in CYFIP proteins. CYRI negatively regulates RAC1 signalling, thereby attenuating processes such as macropinocytosis, phagocytosis and cell migration. This enables CYRI to counteract Salmonella at various stages of infection. The bacterial effector SopE, a RAC1 activator, selectively targets CYRI following infection. | 31285585 |
| 2019-03-16 12:20:00 | Low fam49B expression is associated with pancreatic ductal adenocarcinoma metastasis. | 29059164 |
| 2018-08-18 11:11:00 | FAM49B inhibits T cell activation by repressing Rac activity and modulating cytoskeleton reorganization. | 29632189 |
| 2015-08-08 10:47:00 | Three proteins-matrix metalloproteinase-9, neutrophil elastase, and FAM49B-were significantly lower in abundance in samples from women with endometriosis. | 25284053 |
| 2011-09-14 12:13:00 | FAM49B is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. | 21555518 |
| Type | IDs |
|---|---|
| Synonymous | BM-009, L1 |
| Gene |
UniProtKB-ID:
CYRIB_HUMAN,
A0A024R9G4_HUMAN
UniprotKB:
Q9NUQ9,
A0A024R9G4
UniParc:
UPI000006D1BB,
UPI0000073D89
EMBL:
CH471060,
BC016345,
AC131568,
AK001226,
BC003599,
AK002059,
AC022973,
AY598320,
BC017297,
AF208851
Ensembl:
ENSG00000153310
KO:
hsa:51571
|
| Nucleutide sequences |
EMBL-CDS:
AAT06731.1,
BAA91566.1,
AAH16345.1,
AAH17297.1,
AAF64265.1,
BAA92062.1,
AAH03599.1,
EAW92127.1,
EAW92125.1,
EAW92128.1
Gene_ORFName:
BM-009,
hCG_17915
Ensembl_TRS:
ENST00000519110,
ENST00000401979,
ENST00000523509,
ENST00000517654,
ENST00000519540,
ENST00000519824,
ENST00000522941,
ENST00000522746,
ENST00000522250
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000429802,
ENSP00000384880,
ENSP00000429978,
ENSP00000429150,
ENSP00000429499,
ENSP00000430433,
ENSP00000429078,
ENSP00000428117,
ENSP00000430674
RefSeq:
NP_001340210.1,
NP_001340204.1,
NP_001340219.1,
NP_001243692.1,
XP_016869046.1,
NP_001340206.1,
NP_001340208.1,
NP_001340216.1,
NP_001340228.1,
NP_001340226.1,
NP_001340189.1,
NP_001340201.1,
NP_001340212.1,
NP_001340202.1,
NP_001340187.1,
NP_001340240.1,
XP_016869037.1,
NP_001340225.1,
NP_001340211.1,
NP_001340234.1,
NP_001340223.1,
NP_001340237.1,
NP_001340184.1,
NP_001340194.1,
NP_001340185.1,
NP_001340200.1,
NP_001340182.1,
NP_001340222.1,
NP_001340181.1,
XP_016869040.1,
NP_001340197.1,
NP_001340175.1,
NP_001340191.1,
NP_001340241.1,
NP_001340235.1,
NP_001340203.1,
NP_001340213.1,
NP_001340245.1,
NP_001340205.1,
NP_001340199.1,
NP_001340218.1,
NP_001340230.1,
NP_001340221.1,
NP_001340244.1,
XP_024302948.1,
NP_001340214.1,
NP_001340238.1,
NP_001340239.1,
NP_001340177.1,
NP_001340178.1,
NP_001340180.1,
NP_001340176.1,
NP_001340198.1,
NP_001340188.1,
XP_016869034.1,
NP_001340186.1,
NP_001340172.1,
NP_001340174.1,
NP_001340220.1,
NP_001340236.1,
NP_001340232.1,
NP_001340227.1,
NP_001340190.1,
NP_001340171.1,
NP_001340193.1,
NP_001340207.1,
NP_001340209.1,
XP_011515414.1,
NP_001340242.1,
NP_001340192.1,
NP_001340233.1,
XP_016869043.1,
NP_001340224.1,
NP_001317541.1,
NP_001340243.1,
NP_001340173.1,
NP_001340231.1,
XP_011515423.1,
NP_001340183.1,
NP_001340217.1,
NP_001340229.1,
NP_001340195.1,
NP_057707.3,
NP_001340179.1,
NP_001340196.1,
NP_001340215.1
|
| Others |
UniRef100:
UniRef100_Q9NUQ9
UniRef90:
UniRef90_Q9NUQ9
UniRef50:
UniRef50_Q9NUQ9
UniGene:
Hs.126941
CCDS:
CCDS83327.1,
CCDS6361.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Ensembl: {{protein.nucleotideEnsembl}} |
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Ensembl: {{protein.proteinEnsembl}} |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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