| Type | Description |
|---|---|
| Definition | phosphodiesterase 8A |
| Date | Results | Publications |
|---|---|---|
| 2020-01-18 12:10:00 | Editing of PDE8A mRNA displayed clear regional difference when comparing dorsolateral prefrontal cortex (BA9) and anterior cingulate cortex (BA24). There were significant intra-regional differences between non-psychiatric control individuals and depressed suicide decedents. | 30770787 |
| 2019-07-13 10:48:00 | PDE8 is expressed in lipid rafts of human airway smooth muscle cells(HASM), where it specifically regulates beta2-adrenergic receptor/ AC6 signaling to modulate HASM responsiveness and airway remodeling in asthma. | 29262264 |
| 2017-05-27 11:24:00 | SNPs within genes SCHIP1 and PDE8A were associated with measures of facial size in both the GWAS and replication cohorts and passed a stringent genomewide significance threshold adjusted for multiple testing of 34 correlated traits. For both SCHIP1 and PDE8A, we demonstrated clear expression in the developing mouse face by both whole-mount in situ hybridization and RNA-seq | 27560698 |
| 2015-10-10 10:45:00 | PDE8A supports HIV-1 replication in macrophages | 25295610 |
| 2015-02-21 11:12:00 | a novel and critical role for phosphodiesterases in moderating local concentrations of cAMP in microdomains and signal resetting | 25229150 |
| Type | IDs |
|---|---|
| Synonymous | HsT19550 |
| Gene |
UniProtKB-ID:
PDE8A_HUMAN,
A0A024RC53_HUMAN
UniprotKB:
O60658,
A0A024RC53
UniParc:
UPI000002A6E7,
UPI0000408E08,
UPI00021D633D,
UPI0000127C00,
UPI00021D633C,
UPI00001A8559,
UPI000002A6E9
EMBL:
BC075822,
AF388183,
AK074280,
AF388185,
AC027078,
AF332653,
AC087468,
AL109778,
BC060762,
AF388186,
AF056490,
AL109687,
CH471101,
AF388184,
AK127232,
AF388187
Ensembl:
ENSG00000073417
KO:
hsa:5151
|
| Nucleutide sequences |
EMBL-CDS:
EAX01967.1,
CAB52020.1,
AAL18614.1,
AAH60762.1,
AAK57641.1,
AAC39763.1,
AAL18611.1,
AAL18613.1,
BAG54458.1,
AAL18612.1,
CAB52432.1,
AAL18610.1,
AAH75822.1,
EAX01968.1,
EAX01965.1
Gene_ORFName:
hCG_1991196
Ensembl_TRS:
ENST00000478717,
ENST00000310298,
ENST00000339708,
ENST00000557957,
ENST00000394553
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000311453,
ENSP00000340679,
ENSP00000432309,
ENSP00000378056,
ENSP00000453808
RefSeq:
XP_016877798.1,
XP_016877800.1,
XP_016877799.1,
XP_016877797.1,
NP_002596.1,
NP_001230066.1,
NP_775656.1,
XP_024305715.1,
XP_011519970.1,
XP_024305714.1
|
| Others |
UniRef100:
UniRef100_O60658
UniRef90:
UniRef90_O60658
UniRef50:
UniRef50_O60658
UniGene:
Hs.9333
CCDS:
CCDS10336.1,
CCDS10337.1,
CCDS58397.1
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| 1 |
Biogen Inc., 250 Binney Street, Cambridge, Massachusetts 02142, USA. |
1 |
| 2 |
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA. |
1 |
| 3 |
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. |
1 |
| 4 |
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: steven_gygi@hms.harvard.edu. |
1 |
| 5 |
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: wade_harper@hms.harvard.edu. |
1 |
| 排名 | 研究人员 | 文献 |
|---|---|---|
| 1 |
Joao A Paulo |
2 |
| 2 |
John Szpyt |
2 |
| 3 |
Steven P Gygi |
2 |
| 4 |
Fana Gebreab |
2 |
| 5 |
Edward L Huttlin |
2 |