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5151 PDE8A

5151

PDE8A

phosphodiesterase 8A

protein-coding

Homo sapiens

基因描述

Type Description
Definition phosphodiesterase 8A

研究结论

Date Results Publications
2020-01-18 12:10:00 Editing of PDE8A mRNA displayed clear regional difference when comparing dorsolateral prefrontal cortex (BA9) and anterior cingulate cortex (BA24). There were significant intra-regional differences between non-psychiatric control individuals and depressed suicide decedents. 30770787
2019-07-13 10:48:00 PDE8 is expressed in lipid rafts of human airway smooth muscle cells(HASM), where it specifically regulates beta2-adrenergic receptor/ AC6 signaling to modulate HASM responsiveness and airway remodeling in asthma. 29262264
2017-05-27 11:24:00 SNPs within genes SCHIP1 and PDE8A were associated with measures of facial size in both the GWAS and replication cohorts and passed a stringent genomewide significance threshold adjusted for multiple testing of 34 correlated traits. For both SCHIP1 and PDE8A, we demonstrated clear expression in the developing mouse face by both whole-mount in situ hybridization and RNA-seq 27560698
2015-10-10 10:45:00 PDE8A supports HIV-1 replication in macrophages 25295610
2015-02-21 11:12:00 a novel and critical role for phosphodiesterases in moderating local concentrations of cAMP in microdomains and signal resetting 25229150

名称对应

Type IDs
Synonymous HsT19550
Gene
UniProtKB-ID: PDE8A_HUMAN, A0A024RC53_HUMAN
UniprotKB: O60658, A0A024RC53
UniParc: UPI000002A6E7, UPI0000408E08, UPI00021D633D, UPI0000127C00, UPI00021D633C, UPI00001A8559, UPI000002A6E9
EMBL: BC075822, AF388183, AK074280, AF388185, AC027078, AF332653, AC087468, AL109778, BC060762, AF388186, AF056490, AL109687, CH471101, AF388184, AK127232, AF388187
Ensembl: ENSG00000073417
KO: hsa:5151
Nucleutide sequences
EMBL-CDS: EAX01967.1, CAB52020.1, AAL18614.1, AAH60762.1, AAK57641.1, AAC39763.1, AAL18611.1, AAL18613.1, BAG54458.1, AAL18612.1, CAB52432.1, AAL18610.1, AAH75822.1, EAX01968.1, EAX01965.1
Gene_ORFName: hCG_1991196
Ensembl_TRS: ENST00000478717, ENST00000310298, ENST00000339708, ENST00000557957, ENST00000394553
Protein sequencees
Ensembl_PRO: ENSP00000311453, ENSP00000340679, ENSP00000432309, ENSP00000378056, ENSP00000453808
RefSeq: XP_016877798.1, XP_016877800.1, XP_016877799.1, XP_016877797.1, NP_002596.1, NP_001230066.1, NP_775656.1, XP_024305715.1, XP_011519970.1, XP_024305714.1
Others
UniRef100: UniRef100_O60658
UniRef90: UniRef90_O60658
UniRef50: UniRef50_O60658
UniGene: Hs.9333
CCDS: CCDS10336.1, CCDS10337.1, CCDS58397.1

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研究热度

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