| Type | Description |
|---|---|
| Definition | Hikeshi, heat shock protein nuclear import factor |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:32:00 | HIKESHI silencing can enhance mild hyperthermia sensitivity in human oral squamous cell carcinoma HSC3 cells. | 32377716 |
| 2018-04-21 11:36:00 | Our results suggest that HIKESHI is a marker of cancer progression and that the combination of HIKESHI inhibition and hyperthermia is a therapeutic tool for refractory gastric cancer | 28731175 |
| 2018-03-31 11:17:00 | Depletion of Hikeshi renders HeLa cells proteotoxic stress-sensitive through the abrogation of the nuclear function of HSP70s required for HSF1 regulation. | 28980748 |
| 2017-08-12 11:16:00 | A novel homozygous variant in HIKESHI was identified in a patient with hypomyelinating leukoencephalopathy with periventricular cysts and vermian atrophy. Modified interactions inside Hikeshi's hydrophobic pockets induce mutant protein instability. | 28000699 |
| 2016-11-05 11:58:00 | Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene.P.V54L mutation in Hikeshi is associated with absence of nuclear HSP70 during heat shock stress. | 26545878 |
| Type | IDs |
|---|---|
| Synonymous | C11orf73, HLD13, HSPC138, HSPC179, L7RN6, OPI10 |
| Gene |
UniProtKB-ID:
HIKES_HUMAN
UniprotKB:
Q53FT3
UniParc:
UPI000006CF46
EMBL:
BC015991,
BC006476,
BC018080,
AF161527,
AF151082,
AK001447,
AK223198,
BC021621,
BC001677,
AF161487
Ensembl:
ENSG00000149196
KO:
hsa:51501
|
| Nucleutide sequences |
EMBL-CDS:
BAD96918.1,
AAF36168.1,
AAH01677.1,
AAH18080.1,
AAH06476.1,
AAH15991.1,
AAF29142.1,
AAF29102.1,
AAH21621.1,
BAA91698.1
Gene_ORFName:
HSPC179,
HSPC248,
HSPC138
Ensembl_TRS:
ENST00000278483
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000278483
RefSeq:
NP_001309338.1,
NP_057485.2,
XP_016873404.1,
NP_001309333.1,
XP_016873403.1,
NP_001309336.1
|
| Others |
UniRef100:
UniRef100_Q53FT3
UniRef90:
UniRef90_Q53FT3
UniRef50:
UniRef50_Q53FT3
UniGene:
Hs.283322
CCDS:
CCDS8275.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员