| Type | Description |
|---|---|
| Definition | phosphodiesterase 6G |
| Date | Results | Publications |
|---|---|---|
| 2011-03-26 11:27:00 | Collectively, we report previously unrecognized PDE6 expression in human lungs, significant alterations of the PDE6D and PDE6G/H subunits in IPF lungs. | 20979602 |
| 2010-09-06 11:51:00 | These findings demonstrate the positive role of the gamma subunit in maintaining phosphodiesterase activity and confirm the contribution of PDE6G to the etiology of retinitis pigmentosa in humans. | 20655036 |
| 2010-05-31 11:17:00 | The C-terminus of PED gamma occludes the active site of PDE6, thereby preventing hydrolysis of cGMP. | 20397626 |
| 2010-01-21 00:00:00 | Crystal structures of a chimaeric PDE5/PDE6 catalytic domain (PDE5/6cd) complexed with sildenafil or 3-isobutyl-1-methylxanthine and the Pgamma-inhibitory peptide Pgamma(70-87) have been determined at 2.9 and 3.0 A, respectively. | 19798052 |
| 2010-01-21 00:00:00 | PDEG functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor | 12624098 |
| Type | IDs |
|---|---|
| Synonymous | PDEG, RP57 |
| Gene |
UniProtKB-ID:
CNRG_HUMAN
UniprotKB:
P18545
UniParc:
UPI0000127C39
EMBL:
BC106884,
CH471099,
X62025,
U00482,
BX537414,
M36476,
U00481
Ensembl:
ENSG00000185527
KO:
hsa:5148
|
| Nucleutide sequences |
EMBL-CDS:
CAD97656.1,
EAW89666.1,
AAA03653.1,
AAI06885.1,
AAA60044.1,
CAA43975.1
Ensembl_TRS:
ENST00000571004,
ENST00000571224,
ENST00000331056
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000458167,
ENSP00000461464,
ENSP00000328412
RefSeq:
NP_001352654.1,
XP_016880225.1,
NP_002593.1,
NP_001352653.1
|
| Others |
UniRef100:
UniRef100_P18545
UniRef90:
UniRef90_P18545
UniRef50:
UniRef50_P18545
UniGene:
Hs.654482
CCDS:
CCDS11783.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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