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5148 PDE6G

5148

PDE6G

phosphodiesterase 6G

protein-coding

Homo sapiens

基因描述

Type Description
Definition phosphodiesterase 6G

研究结论

Date Results Publications
2011-03-26 11:27:00 Collectively, we report previously unrecognized PDE6 expression in human lungs, significant alterations of the PDE6D and PDE6G/H subunits in IPF lungs. 20979602
2010-09-06 11:51:00 These findings demonstrate the positive role of the gamma subunit in maintaining phosphodiesterase activity and confirm the contribution of PDE6G to the etiology of retinitis pigmentosa in humans. 20655036
2010-05-31 11:17:00 The C-terminus of PED gamma occludes the active site of PDE6, thereby preventing hydrolysis of cGMP. 20397626
2010-01-21 00:00:00 Crystal structures of a chimaeric PDE5/PDE6 catalytic domain (PDE5/6cd) complexed with sildenafil or 3-isobutyl-1-methylxanthine and the Pgamma-inhibitory peptide Pgamma(70-87) have been determined at 2.9 and 3.0 A, respectively. 19798052
2010-01-21 00:00:00 PDEG functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor 12624098

名称对应

Type IDs
Synonymous PDEG, RP57
Gene
UniProtKB-ID: CNRG_HUMAN
UniprotKB: P18545
UniParc: UPI0000127C39
EMBL: BC106884, CH471099, X62025, U00482, BX537414, M36476, U00481
Ensembl: ENSG00000185527
KO: hsa:5148
Nucleutide sequences
EMBL-CDS: CAD97656.1, EAW89666.1, AAA03653.1, AAI06885.1, AAA60044.1, CAA43975.1
Ensembl_TRS: ENST00000571004, ENST00000571224, ENST00000331056
Protein sequencees
Ensembl_PRO: ENSP00000458167, ENSP00000461464, ENSP00000328412
RefSeq: NP_001352654.1, XP_016880225.1, NP_002593.1, NP_001352653.1
Others
UniRef100: UniRef100_P18545
UniRef90: UniRef90_P18545
UniRef50: UniRef50_P18545
UniGene: Hs.654482
CCDS: CCDS11783.1

全选

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