| Type | Description |
|---|---|
| Definition | leucine carboxyl methyltransferase 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-02-24 10:59:00 | We demonstrate that NNMT outcompetes leucine carboxyl methyl transferase 1 (LCMT1) for methyl transfer from principal methyl donor SAM in biological systems. Inhibiting NNMT increased the availability of methyl groups for LCMT1 to methylate PP2A, resulting in the inhibition of oncogenic serine/threonine kinases (STK). | 27810903 |
| 2016-04-23 12:01:00 | LCMT1-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division | 25839665 |
| 2013-11-30 12:41:00 | alterations in the membrane localization of PP2A and Tau following down-regulation of LCMT1 may lead to PP2A and Tau dysfunction in AD. | 23943618 |
| 2013-04-13 10:54:00 | Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled. | 22443683 |
| 2012-10-13 10:25:00 | GSK-3beta can inhibit PP2A by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 | 22732552 |
| Type | IDs |
|---|---|
| Synonymous | CGI-68, LCMT, PPMT1 |
| Gene |
UniProtKB-ID:
LCMT1_HUMAN
UniprotKB:
Q9UIC8
UniParc:
UPI00005B2DFC,
UPI000007016B,
UPI0000000C29
EMBL:
AL137283,
AK291885,
BC001214,
AF037601,
AC133552,
BC014217,
AK025884,
AK223364,
AF151826,
AC008741,
AK314409
Ensembl:
ENSG00000205629
KO:
hsa:51451
|
| Nucleutide sequences |
EMBL-CDS:
CAB70677.1,
AAH14217.1,
AAH01214.1,
BAB15270.1,
AAF18267.1,
AAD34063.1,
BAF84574.1,
BAD97084.1,
BAG37031.1
Gene_ORFName:
CGI-68
Ensembl_TRS:
ENST00000380966,
ENST00000399069
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000382021,
ENSP00000370353
RefSeq:
XP_011544164.1,
XP_011544166.1,
NP_057393.2,
XP_005255411.1,
NP_001027563.1
|
| Others |
UniRef100:
UniRef100_Q9UIC8
UniRef90:
UniRef90_Q9UIC8
UniRef50:
UniRef50_Q9UIC8
UniGene:
Hs.337730
CCDS:
CCDS45446.1,
CCDS45445.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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