| Type | Description |
|---|---|
| Definition | DEAD-box helicase 41 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-29 12:46:00 | Herpes Simplex Virus Type 1-Encoded miR-H2-3p Manipulates Cytosolic DNA-Stimulated Antiviral Innate Immune Response by Targeting DDX41. | 31443275 |
| 2020-03-14 10:43:00 | Patients with myeloid neoplasms carrying DDX41 mutations show male predominance (3:1), higher age at presentation, association with TP53 mutations, and association with high-grade myeloid neoplasms in our cohort at a referral cancer center setting. | 30963592 |
| 2020-02-22 10:29:00 | This study highlights that germline DDX41 mutations are relatively common in adult myelodysplastic syndromes and acute myeloid leukemias often without known family history, arguing for systematic screening. | 31484648 |
| 2019-03-02 11:01:00 | bi-allelic mutations in DDX41 could potentially be a new cancer predisposition syndrome associated with delayed psychomotor development | 30144193 |
| 2018-07-07 11:37:00 | Results show that the DDX41 DEAD domain recognizes both double-stranded DNA (dsDNA) and cyclic dinucleotides (CDN) at the same binding site. A structural comparison between the open and closed forms of the DDX41 DEAD domain revealed the structural rearrangement in the N-terminal region, which drastically changes the conformation of the ATP-binding site. | 27721487 |
| Type | IDs |
|---|---|
| Synonymous | ABS, MPLPF |
| Gene |
UniProtKB-ID:
DDX41_HUMAN,
B3KRK2_HUMAN
UniprotKB:
Q9UJV9,
B3KRK2
UniParc:
UPI0000EE7CA6,
UPI0000125164
EMBL:
AK001255,
AL137455,
AK027768,
BC015476,
AK091774,
AK315491,
CH471195,
AF195417,
BX641072
Ensembl:
ENSG00000183258
KO:
hsa:51428
|
| Nucleutide sequences |
EMBL-CDS:
CAE46035.1,
AAH15476.1,
AAF04150.1,
BAB55355.1,
BAG37875.1,
EAW84981.1,
CAB70746.1,
BAA91585.1,
EAW84980.1,
EAW84977.1,
BAG52414.1
Gene_ORFName:
hCG_2039392
Ensembl_TRS:
ENST00000330503
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000330349
RefSeq:
XP_024301877.1,
NP_001308759.1,
NP_001308661.1,
NP_057306.2
|
| Others |
UniRef100:
UniRef100_Q9UJV9,
UniRef100_B3KRK2
UniRef90:
UniRef90_Q9UJV9,
UniRef90_B3KRK2
UniRef50:
UniRef50_A0A1Y2DRP6,
UniRef50_Q9UJV9
UniGene:
Hs.484288
CCDS:
CCDS4427.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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