| Type | Description |
|---|---|
| Definition | phosphodiesterase 4A |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 12:58:00 | Overexpression of PDE4A Acts as Checkpoint Inhibitor Against cAMP-Mediated Immunosuppression in vitro. | 31417563 |
| 2020-05-23 10:55:00 | these results suggest that FCPR16 (PDE4 Inhibitor)is effective in protecting SH-SY5Y cells and neurons against oxidative stress via AMPK-dependent autophagy. Our findings indicate the potential application of FCPR16 in Parkinson's disease (PD) treatment. | 30818055 |
| 2019-12-14 10:12:00 | These findings suggest that autophagy induces TGF-b1 expression and EMT in hepatocarcinoma cells via signalling, which is activated by autophagy-dependent PDE4A degradation | 30134011 |
| 2019-10-26 12:43:00 | In human large intestinal circular muscle, the intracellular pathway of 5-HT4 receptors facilitating cholinergic neurotransmission to large intestinal circular smooth muscle is controlled by phosphodiesterase 4. | 28799255 |
| 2019-08-31 10:08:00 | PDE4 and Epac1 expression levels are increased in rectal carcinoma tissues, suggesting that the two proteins may be involved in the development of this malignancy. Meanwhile, correlations between PDE4 and Epac1, PDE4 and Cx43, PDE4 and cyclin E1, and Epac1 and Cx43 suggested synergistic effects of these proteins in promoting rectal carcinoma. | 30809467 |
| Type | IDs |
|---|---|
| Synonymous | DPDE2, PDE4, PDE46 |
| Gene |
UniProtKB-ID:
PDE4A_HUMAN
UniprotKB:
P27815
UniParc:
UPI000035DB82,
UPI0000E44575,
UPI0000047003,
UPI000006E35E,
UPI0000047004,
UPI00001697FF,
UPI000002A6D0
EMBL:
BC038234,
U97584,
U18087,
AC011529,
AF069487,
S75213,
AF073745,
AC011461,
AF069488,
AY593872,
AC011548,
AY618547,
U18088,
CH471106,
M37744,
AF069491,
AF069489,
U68532,
BC019864,
AF069490,
L20965
Ensembl:
ENSG00000065989
KO:
hsa:5141
|
| Nucleutide sequences |
EMBL-CDS:
AAC35013.1,
AAC25679.1,
AAC50458.1,
AAA69697.1,
EAW84105.1,
AAC63832.1,
AAC35014.1,
AAD34217.2,
AAC35012.1,
AAB33798.1,
AAT00628.1,
AAH38234.1,
AAU82096.1,
EAW84104.1,
AAA98540.1,
EAW84108.1,
AAA03588.1,
AAC35015.1,
AAH19864.1
Ensembl_TRS:
ENST00000293683,
ENST00000380702,
ENST00000344979,
ENST00000592685,
ENST00000440014
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000370078,
ENSP00000293683,
ENSP00000468507,
ENSP00000341007,
ENSP00000394754
RefSeq:
XP_011526356.1,
XP_024307302.1,
XP_011526357.1,
NP_006193.1,
NP_001230050.1,
XP_016882354.1,
NP_001104777.1,
NP_001104778.1,
NP_001104779.1
|
| Others |
UniRef100:
UniRef100_P27815
UniRef90:
UniRef90_P27815
UniRef50:
UniRef50_Q08499
UniGene:
Hs.89901
CCDS:
CCDS45961.1,
CCDS58649.1,
CCDS12238.1,
CCDS45962.1,
CCDS45963.1
|
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|---|---|---|---|---|---|---|---|---|
| Refseq |
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