| Type | Description |
|---|---|
| Definition | phosphodiesterase 1C |
| Date | Results | Publications |
|---|---|---|
| 2019-03-30 10:53:00 | By combining population-specific mutation arrays, targeted deafness genes panel, whole exome sequencing (WES), we identified PDE1C (Phosphodiesterase 1C) c.958G>T (p.A320S) as the disease-associated variant. Structural modeling insights into p.A320S strongly suggest that the sequence alteration will likely affect the substrate-binding pocket of PDE1C. | 29860631 |
| 2016-06-28 11:30:00 | PDE1C is a proliferation-associated gene in glioblastoma multiforme cells in vitro. | 25620587 |
| 2015-06-20 10:51:00 | PDE1C is an important regulator of SMC proliferation, migration, and neointimal hyperplasia, in part through modulating endosome/lysosome-dependent PDGFRbeta protein degradation via low-density lipoprotein receptor-related protein-1. | 25608528 |
| 2010-06-30 22:05:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| 2010-04-07 21:40:00 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | 20110084 |
| Type | IDs |
|---|---|
| Synonymous | DFNA74, Hcam3, cam-PDE 1C, hCam-3 |
| Gene |
UniProtKB-ID:
PDE1C_HUMAN,
A0A0A0MS69_HUMAN
UniprotKB:
Q14123,
A0A0A0MS69
UniParc:
UPI000292A276,
UPI000002A6C9,
UPI0000127BE9,
UPI00043788D1
EMBL:
KF511020,
AC004931,
AC005589,
AC006377,
AC007033,
AK056170,
AC007093,
AC018637,
AK091734,
U40371,
KF511018,
U40372,
KF458427
Ensembl:
ENSG00000154678
KO:
hsa:5137
|
| Nucleutide sequences |
EMBL-CDS:
AAA96961.1,
BAG51638.1,
AAC50437.1,
BAC03734.1
Ensembl_TRS:
ENST00000396182,
ENST00000396184,
ENST00000321453,
ENST00000396191,
ENST00000396193
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000379494,
ENSP00000379485,
ENSP00000379487,
ENSP00000318105,
ENSP00000379496
RefSeq:
NP_001308985.1,
XP_016867756.1,
NP_001308987.1,
NP_001177987.2,
NP_001177986.1,
XP_016867754.1,
NP_001177985.1,
NP_001308988.1,
XP_016867755.1,
NP_005011.1,
NP_001177988.1,
NP_001308984.1,
NP_001308986.1,
XP_016867753.1
|
| Others |
UniRef100:
UniRef100_Q14123,
UniRef100_A0A0A0MS69
UniRef90:
UniRef90_Q14123
UniRef50:
UniRef50_Q14123
UniGene:
Hs.728862
CCDS:
CCDS5437.1,
CCDS55099.1,
CCDS55100.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员