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51361 HOOK1

51361

HOOK1

hook microtubule tethering protein 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition hook microtubule tethering protein 1

研究结论

Date Results Publications
2019-10-26 10:21:00 No significant correlation between Hook1 expression and outcome in thyroid carcinoma. 29953894
2019-09-21 11:20:00 unreported mutation in HOOK1 gene was identified, which might be responsible to some patients with decapitated and decaudated spermatozoa (DDS) syndrome. Further studies need to uncover the molecular mechanism of spermiogenesis for genomic therapy. 29330334
2017-07-29 13:08:00 Hook1 knockdown promoted epithelial-mesenchymal transition and attenuated the sensitivity of hepatocellular carcinoma cells to doxorubicin. In summary, our results indicate that downregulation of Hook1 plays a pivotal role in hepatocellular carcinoma progression via epithelial-mesenchymal transition. Hook1 may be used as a novel marker and therapeutic molecular target in hepatocellular carcinoma 28718370
2017-05-13 22:22:00 Single-molecule motility assays using total internal reflection fluorescence microscopy indicate that both Hook1 and Hook3 effectively activate cytoplasmic dynein, inducing longer run lengths and higher velocities than the previously characterized dynein activator bicaudal D2 (BICD2). 27365401
2015-03-07 11:05:00 SHP2 positively regulates TGFbeta1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1. 25331952

名称对应

Type IDs
Synonymous HK1
Gene
UniProtKB-ID: HOOK1_HUMAN
UniprotKB: Q9UJC3
UniParc: UPI00017A828B, UPI0000071E61
EMBL: AK292314, AK301768, CH471059, AL035416, AF044923, AC113175, BC011621
Ensembl: ENSG00000134709
KO: hsa:51361
Nucleutide sequences
EMBL-CDS: EAX06615.1, BAG63227.1, AAH11621.1, BAF85003.1, AAC09298.1
Ensembl_TRS: ENST00000371208
Protein sequencees
Ensembl_PRO: ENSP00000360252
RefSeq: XP_011539865.1, XP_006710739.1, XP_024303288.1, NP_056972.1, XP_011539864.1, XP_016856913.1
Others
UniRef100: UniRef100_Q9UJC3
UniRef90: UniRef90_Q9UJC3
UniRef50: UniRef50_Q9UJC3
UniGene: Hs.378836
CCDS: CCDS612.1

全选

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研究热度

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