| Type | Description |
|---|---|
| Definition | phosphodiesterase 1A |
| Date | Results | Publications |
|---|---|---|
| 2019-01-12 11:40:00 | the p-substituted benzyl side chain at N2-position helps to enhance the PDE1 inhibitory profile. Depending on these observations, some new molecules are predicted that may possess better PDE1 inhibition | 28132591 |
| 2018-06-30 10:42:00 | evidence that the rs182089527 mutation in PDE1A is involved in the development of nephrolithiasis and kidney cysts. | 29262781 |
| 2015-12-26 10:50:00 | Report significant associations of PDE1A single nucleotide polymorphisms with diastolic blood pressure and carotid intima-media thickness. | 26464516 |
| 2012-03-31 10:05:00 | These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis | 22012077 |
| 2011-02-26 10:49:00 | PDE1A is suggested to be involved in epigenetic mechanisms by targeting the epigenetic integrator UHRF1. | 20807569 |
| Type | IDs |
|---|---|
| Synonymous | CAM-PDE 1A, CAM-PDE-1A, HCAM-1, HCAM1, HSPDE1A |
| Gene |
UniProtKB-ID:
PDE1A_HUMAN,
B7Z226_HUMAN,
B7Z7A2_HUMAN,
Q9Y633_HUMAN
UniprotKB:
P54750,
B7Z226,
B7Z7A2,
Q9Y633
UniParc:
UPI00000737DB,
UPI000003B33F,
UPI000002A6C7,
UPI0000001072,
UPI000002A6C1,
UPI000002A6C2,
UPI000006E152,
UPI0001914D84,
UPI00001694EB,
UPI000002A6C5,
UPI0001915264,
UPI000002A6C6
EMBL:
CH471058,
BC022480,
AK301720,
U40370,
AL110263,
AB038224,
AF110238,
AK294239,
AJ401610
Ensembl:
ENSG00000115252
KO:
hsa:5136
|
| Nucleutide sequences |
EMBL-CDS:
BAB20051.1,
BAB20050.1,
BAB20053.1,
EAX10966.1,
CAC82208.1,
EAX10974.1,
BAB20049.1,
BAB20056.1,
CAB53703.1,
AAH22480.1,
BAB20052.1,
BAB20054.1,
BAB20055.1,
BAB20057.1,
AAC50436.1,
BAH11712.1,
BAH13538.1,
AAD40740.1
Ensembl_TRS:
ENST00000435564,
ENST00000409365,
ENST00000351439,
ENST00000410103,
ENST00000358139
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000350858,
ENSP00000410309,
ENSP00000309269,
ENSP00000387037,
ENSP00000386767
RefSeq:
NP_001245243.1,
XP_024308727.1,
NP_001350800.1,
XP_011509626.1,
XP_011509627.1,
XP_016859789.1,
XP_016859790.1,
NP_001245241.1,
NP_001003683.1,
XP_016859786.1,
XP_016859787.1,
NP_005010.2,
XP_016859785.1,
XP_016859783.1,
XP_011509625.1,
XP_011509628.1,
XP_016859784.1,
XP_016859788.1,
NP_001245242.1
|
| Others |
UniRef100:
UniRef100_B7Z226,
UniRef100_B7Z3A7,
UniRef100_P54750,
UniRef100_B7Z7A2
UniRef90:
UniRef90_P54750-9,
UniRef90_P54750
UniRef50:
UniRef50_P54750
UniGene:
Hs.191046,
Hs.742174
CCDS:
CCDS2285.1,
CCDS74612.1,
CCDS86900.1,
CCDS58741.1,
CCDS33344.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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