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51343 FZR1

51343

FZR1

fizzy and cell division cycle 20 related 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition fizzy and cell division cycle 20 related 1

研究结论

Date Results Publications
2021-03-28 19:06:00 CDH1 binds MAD2L2 in a Rev1-like pattern. 32811646
2021-03-13 13:22:00 E3 Ubiquitin Ligase APC/C(Cdh1) Negatively Regulates FAH Protein Stability by Promoting Its Polyubiquitination. 33218190
2020-12-26 13:11:00 APC/Cdh1 targets PECAM-1 for ubiquitination and degradation in endothelial cells. 31489637
2019-12-14 10:54:00 Dephosphorylation of FZR1 by PRL-3 facilitates the activity of APC/C(FZR1) by destabilizing AURKA, thus influencing aggressive characteristics and overall progression of colorectal cancer. 30498084
2019-01-11 15:17:00 MAD2L2 helps to ensure a robustly bistable switch between APC/C(CDC20) and APC/C(CDH1) during the metaphase-to-anaphase transition, thereby contributing to mitotic fidelity. 24100295

名称对应

Type IDs
Synonymous CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1
Gene
UniProtKB-ID: FZR1_HUMAN
UniprotKB: Q9UM11
UniParc: UPI00001D6A23, UPI000006D44C, UPI00001695E1
EMBL: AF433157, AB033068, AB013462, AF102508, AC005786, BT007115, AF080397, AC005787, AB013463, BC013413, AF102507, AF083810
Ensembl: ENSG00000105325
KO: hsa:51343
Nucleutide sequences
EMBL-CDS: AAD26623.1, AAC62835.1, AAD52030.1, BAA86954.1, AAF20266.1, AAH13413.1, BAA86955.1, AAD26624.1, AAL28117.1, BAA86556.1, AAC62836.1, AAP35779.1
Ensembl_TRS: ENST00000313639, ENST00000441788, ENST00000395095, ENST00000652521
Protein sequencees
Ensembl_PRO: ENSP00000498659, ENSP00000321800, ENSP00000410369, ENSP00000378529
RefSeq: NP_001129670.1, NP_001129669.1, XP_005259630.1, XP_016882352.1, NP_057347.2
Others
UniRef100: UniRef100_Q9UM11
UniRef90: UniRef90_Q9UM11
UniRef50: UniRef50_Q9UM11
UniGene: Hs.413133
CCDS: CCDS45916.1, CCDS45917.1, CCDS12109.1

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