| Type | Description |
|---|---|
| Definition | alpha hemoglobin stabilizing protein |
| Date | Results | Publications |
|---|---|---|
| 2019-07-27 13:14:00 | The study documents that among the HbE beta thalassemia patients with varying severity, an exon mutation in AHSP is significantly prevalent only among the transfusion-dependent beta-thalassemia patients. | 31190133 |
| 2017-11-25 14:07:00 | In the presence of free alpha subunits and H2O2, both HbA and HbE showed bCys93 oxidation which increased with higher H2O2 concentrations. In the presence of Alpha-hemoglobin stabilizing protein (AHSP)Cys93 oxidation was substantially reduced in both proteins.in the presence of excess free alpha-subunit and under the same oxidative conditions, these events are substantially increased for HbE compared to HbA | 26995402 |
| 2017-08-19 12:21:00 | Findings indicate that alpha-hemoglobin-stabilizing protein (AHSP) expression is a biomarker of hemoglobin H (HbH) disease severity and infer an important role of AHSP in modulating the pathophysiology of this disease. | 28337528 |
| 2016-09-17 10:14:00 | AHSP is predominantly expressed in erythroid precursors in bone marrow biopsy specimens from patients with hematologic malignancies. | 25611244 |
| 2016-07-30 11:49:00 | AHSP expression was higher in patients with sickle cell anemia versus thalassemia, with no significant difference between BTM and BTI. Expression was higher in patients with NTDT and on hydroxyurea therapy. | 26460260 |
| Type | IDs |
|---|---|
| Synonymous | EDRF, ERAF |
| Gene |
UniProtKB-ID:
AHSP_HUMAN,
Q549J4_HUMAN
UniprotKB:
Q9NZD4,
Q549J4
UniParc:
UPI0000001C48
EMBL:
AF364517,
AF208865,
AY072612,
AF485325,
CH471192,
BC035842,
AF112995
Ensembl:
ENSG00000169877
KO:
hsa:51327
|
| Nucleutide sequences |
EMBL-CDS:
AAL82894.1,
AAH35842.1,
AAK50856.1,
AAF64279.1,
AAO49381.1,
EAW52118.1,
AAP97228.1
Gene_ORFName:
hCG_1772004
Ensembl_TRS:
ENST00000302312
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000307199
RefSeq:
NP_057717.1,
NP_001305150.1,
NP_001305151.1
|
| Others |
UniRef100:
UniRef100_Q9NZD4
UniRef90:
UniRef90_Q9NZD4
UniRef50:
UniRef50_Q9NZD4
UniGene:
Hs.274309
CCDS:
CCDS10716.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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