| Type | Description |
|---|---|
| Definition | NME/NM23 family member 8 |
| Date | Results | Publications |
|---|---|---|
| 2017-12-30 12:39:00 | Studies suggest that the rs2718058 near gene NME8 on chromosome 7p14.1 might not play a major role in the genetic predisposition to late-onset Alzheimer's disease (LOAD) in the North Han Chinese. | 27144521 |
| 2017-09-23 10:45:00 | Addition of the minor allele for rs670139 (MS4A4E), rs9331896 (CLU), and rs12155159 (NME8) was nominally associated with change on the DWRT, and WFT, respectively, in whites. | 27781389 |
| 2016-01-16 12:01:00 | NME8 locus polymorphism is associated with cognitive decline, cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease. | 25486118 |
| 2015-06-20 10:18:00 | GPR141-NME8 locus had strong genetic effect on the susceptibility to generalized periodontitis in Japanese individuals with history of smoking. identified 2 suggestive loci for periodontitis in a Japanese population. | 25672891 |
| 2010-06-30 22:05:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| Type | IDs |
|---|---|
| Synonymous | CILD6, HEL-S-99, NM23-H8, SPTRX2, TXNDC3, sptrx-2 |
| Gene |
UniProtKB-ID:
TXND3_HUMAN
UniprotKB:
Q8N427
UniParc:
UPI00000700CB
EMBL:
AF305596,
AC018634,
AF202051,
BC036816
Ensembl:
ENSG00000086288
KO:
hsa:51314
|
| Nucleutide sequences |
EMBL-CDS:
AAH36816.1,
AAF20909.2,
AAN04258.1
Ensembl_TRS:
ENST00000440017,
ENST00000199447
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000199447,
ENSP00000397063
RefSeq:
NP_057700.3
|
| Others |
UniRef100:
UniRef100_Q8N427
UniRef90:
UniRef90_Q8N427
UniRef50:
UniRef50_Q8N427
UniGene:
Hs.723454
CCDS:
CCDS5452.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 29987050 |
Proc. Natl. Acad. Sci. U.S.A. Tengfei Xiao , Wei Li , Xiaoqing Wang , Han Xu , Jixin Yang , Qiu Wu , Ying Huang , Joseph Geradts , Peng Jiang , Teng Fei , David Chi , Chongzhi Zang , Qi Liao , Jonathan Rennhack , Eran Andrechek , Nanlin Li , Simone Detre , Mitchell Dowsett , Rinath M Jeselsohn , X Shirley Liu , Myles Brown |
2018-07-31 | - |
| 29883609 |
PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation. Mol. Cell Seung-Won Choi , Han-Hee Park , Soyeon Kim , Jee Min Chung , Hyun-Jin Noh , Sue Kyung Kim , Hyun Kyu Song , Chang-Woo Lee , Michael J Morgan , Ho Chul Kang , You-Sun Kim |
2018-06-07 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 27781389 |
Am J Med Genet B Neuropsychiatr Genet Jan Bressler , Thomas H Mosley , Alan Penman , Rebecca F Gottesman , Beverly Gwen Windham , David S Knopman , Lisa M Wruck , Eric Boerwinkle |
2017-04-01 | - |
| 27144521 |
NME8 rs2718058 polymorphism with Alzheimer's disease risk: a replication and meta-analysis. Oncotarget Shu-Lei Liu , Xue-Chun Wang , Meng-Shan Tan , Hui-Fu Wang , Wei Zhang , Zi-Xuan Wang , Jin-Tai Yu , Lan Tan |
2016-06-14 | - |
| 27173435 |
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun Karsten Boldt , Jeroen van Reeuwijk , Qianhao Lu , Konstantinos Koutroumpas , Thanh-Minh T Nguyen , Yves Texier , Sylvia E C van Beersum , Nicola Horn , Jason R Willer , Dorus A Mans , Gerard Dougherty , Ideke J C Lamers , Karlien L M Coene , Heleen H Arts , Matthew J Betts , Tina Beyer , Emine Bolat , Christian Johannes Gloeckner , Khatera Haidari , Lisette Hetterschijt , Daniela Iaconis , Dagan Jenkins , Franziska Klose , Barbara Knapp , Brooke Latour , Stef J F Letteboer , Carlo L Marcelis , Dragana Mitic , Manuela Morleo , Machteld M Oud , Moniek Riemersma , Susan Rix , Paulien A Terhal , Grischa Toedt , Teunis J P van Dam , Erik de Vrieze , Yasmin Wissinger , Ka Man Wu , Gordana Apic , Philip L Beales , Oliver E Blacque , Toby J Gibson , Martijn A Huynen , Nicholas Katsanis , Hannie Kremer , Heymut Omran , Erwin van Wijk , Uwe Wolfrum , François Kepes , Erica E Davis , Brunella Franco , Rachel H Giles , Marius Ueffing , Robert B Russell , Ronald Roepman , UK10K Rare Diseases Group |
2016-05-13 | - |
| 25672891 |
A genome-wide association study of periodontitis in a Japanese population. J. Dent. Res. S Shimizu , Y Momozawa , A Takahashi , T Nagasawa , K Ashikawa , Y Terada , Y Izumi , H Kobayashi , M Tsuji , M Kubo , Y Furuichi |
2015-04-01 |
GPR141,
NME8,
KCNQ5
|
| 25486118 |
PLoS One Ying Liu , Jin-Tai Yu , Hui-Fu Wang , Xiao-Ke Hao , Yu-Fen Yang , Teng Jiang , Xi-Chen Zhu , Lei Cao , Dao-Qiang Zhang , Lan Tan |
2014-01-01 | - |
| 24162737 |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet J C Lambert , C A Ibrahim-Verbaas , D Harold , A C Naj , R Sims , C Bellenguez , A L DeStafano , J C Bis , G W Beecham , B Grenier-Boley , G Russo , T A Thorton-Wells , N Jones , A V Smith , V Chouraki , C Thomas , M A Ikram , D Zelenika , B N Vardarajan , Y Kamatani , C F Lin , A Gerrish , H Schmidt , B Kunkle , M L Dunstan , A Ruiz , M T Bihoreau , S H Choi , C Reitz , F Pasquier , C Cruchaga , D Craig , N Amin , C Berr , O L Lopez , P L De Jager , V Deramecourt , J A Johnston , D Evans , S Lovestone , L Letenneur , F J Morón , D C Rubinsztein , G Eiriksdottir , K Sleegers , A M Goate , N Fiévet , M W Huentelman , M Gill , K Brown , M I Kamboh , L Keller , P Barberger-Gateau , B McGuiness , E B Larson , R Green , A J Myers , C Dufouil , S Todd , D Wallon , S Love , E Rogaeva , J Gallacher , P St George-Hyslop , J Clarimon , A Lleo , A Bayer , D W Tsuang , L Yu , M Tsolaki , P Bossù , G Spalletta , P Proitsi , J Collinge , S Sorbi , F Sanchez-Garcia , N C Fox , J Hardy , M C Deniz Naranjo , P Bosco , R Clarke , C Brayne , D Galimberti , M Mancuso , F Matthews , European Alzheimer's Disease Initiative (EADI) , Genetic and Environmental Risk in Alzheimer's Disease , Alzheimer's Disease Genetic Consortium , Cohorts for Heart and Aging Research in Genomic Epidemiology , S Moebus , P Mecocci , M Del Zompo , W Maier , H Hampel , A Pilotto , M Bullido , F Panza , P Caffarra , B Nacmias , J R Gilbert , M Mayhaus , L Lannefelt , H Hakonarson , S Pichler , M M Carrasquillo , M Ingelsson , D Beekly , V Alvarez , F Zou , O Valladares , S G Younkin , E Coto , K L Hamilton-Nelson , W Gu , C Razquin , P Pastor , I Mateo , M J Owen , K M Faber , P V Jonsson , O Combarros , M C O'Donovan , L B Cantwell , H Soininen , D Blacker , S Mead , T H Mosley , D A Bennett , T B Harris , L Fratiglioni , C Holmes , R F de Bruijn , P Passmore , T J Montine , K Bettens , J I Rotter , A Brice , K Morgan , T M Foroud , W A Kukull , D Hannequin , J F Powell , M A Nalls , K Ritchie , K L Lunetta , J S Kauwe , E Boerwinkle , M Riemenschneider , M Boada , M Hiltuenen , E R Martin , R Schmidt , D Rujescu , L S Wang , J F Dartigues , R Mayeux , C Tzourio , A Hofman , M M Nöthen , C Graff , B M Psaty , L Jones , J L Haines , P A Holmans , M Lathrop , M A Pericak-Vance , L J Launer , L A Farrer , C M van Duijn , C Van Broeckhoven , V Moskvina , S Seshadri , J Williams , G D Schellenberg , P Amouyel |
2013-12-01 | - |
| 22504420 |
Nat. Genet. Karol Estrada , Unnur Styrkarsdottir , Evangelos Evangelou , Yi-Hsiang Hsu , Emma L Duncan , Evangelia E Ntzani , Ling Oei , Omar M E Albagha , Najaf Amin , John P Kemp , Daniel L Koller , Guo Li , Ching-Ti Liu , Ryan L Minster , Alireza Moayyeri , Liesbeth Vandenput , Dana Willner , Su-Mei Xiao , Laura M Yerges-Armstrong , Hou-Feng Zheng , Nerea Alonso , Joel Eriksson , Candace M Kammerer , Stephen K Kaptoge , Paul J Leo , Gudmar Thorleifsson , Scott G Wilson , James F Wilson , Ville Aalto , Markku Alen , Aaron K Aragaki , Thor Aspelund , Jacqueline R Center , Zoe Dailiana , David J Duggan , Melissa Garcia , Natà lia Garcia-Giralt , Sylvie Giroux , Göran Hallmans , Lynne J Hocking , Lise Bjerre Husted , Karen A Jameson , Rita Khusainova , Ghi Su Kim , Charles Kooperberg , Theodora Koromila , Marcin Kruk , Marika Laaksonen , Andrea Z Lacroix , Seung Hun Lee , Ping C Leung , Joshua R Lewis , Laura Masi , Simona Mencej-Bedrac , Tuan V Nguyen , Xavier Nogues , Millan S Patel , Janez Prezelj , Lynda M Rose , Serena Scollen , Kristin Siggeirsdottir , Albert V Smith , Olle Svensson , Stella Trompet , Olivia Trummer , Natasja M van Schoor , Jean Woo , Kun Zhu , Susana Balcells , Maria Luisa Brandi , Brendan M Buckley , Sulin Cheng , Claus Christiansen , Cyrus Cooper , George Dedoussis , Ian Ford , Morten Frost , David Goltzman , Jesús González-MacÃas , Mika Kähönen , Magnus Karlsson , Elza Khusnutdinova , Jung-Min Koh , Panagoula Kollia , Bente Lomholt Langdahl , William D Leslie , Paul Lips , Ãsten Ljunggren , Roman S Lorenc , Janja Marc , Dan Mellström , Barbara Obermayer-Pietsch , José M Olmos , Ulrika Pettersson-Kymmer , David M Reid , José A Riancho , Paul M Ridker , François Rousseau , P Eline Slagboom , Nelson L S Tang , Roser Urreizti , Wim Van Hul , Jorma Viikari , MarÃa T Zarrabeitia , Yurii S Aulchenko , Martha Castano-Betancourt , Elin Grundberg , Lizbeth Herrera , Thorvaldur Ingvarsson , Hrefna Johannsdottir , Tony Kwan , Rui Li , Robert Luben , Carolina Medina-Gómez , Stefan Th Palsson , Sjur Reppe , Jerome I Rotter , Gunnar Sigurdsson , Joyce B J van Meurs , Dominique Verlaan , Frances M K Williams , Andrew R Wood , Yanhua Zhou , Kaare M Gautvik , Tomi Pastinen , Soumya Raychaudhuri , Jane A Cauley , Daniel I Chasman , Graeme R Clark , Steven R Cummings , Patrick Danoy , Elaine M Dennison , Richard Eastell , John A Eisman , Vilmundur Gudnason , Albert Hofman , Rebecca D Jackson , Graeme Jones , J Wouter Jukema , Kay-Tee Khaw , Terho Lehtimäki , Yongmei Liu , Mattias Lorentzon , Eugene McCloskey , Braxton D Mitchell , Kannabiran Nandakumar , Geoffrey C Nicholson , Ben A Oostra , Munro Peacock , Huibert A P Pols , Richard L Prince , Olli Raitakari , Ian R Reid , John Robbins , Philip N Sambrook , Pak Chung Sham , Alan R Shuldiner , Frances A Tylavsky , Cornelia M van Duijn , Nick J Wareham , L Adrienne Cupples , Michael J Econs , David M Evans , Tamara B Harris , Annie Wai Chee Kung , Bruce M Psaty , Jonathan Reeve , Timothy D Spector , Elizabeth A Streeten , M Carola Zillikens , Unnur Thorsteinsdottir , Claes Ohlsson , David Karasik , J Brent Richards , Matthew A Brown , Kari Stefansson , André G Uitterlinden , Stuart H Ralston , John P A Ioannidis , Douglas P Kiel , Fernando Rivadeneira |
2012-04-15 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员