| Type | Description |
|---|---|
| Definition | membrane associated ring-CH-type finger 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-07 11:44:00 | MARCH2 reduced secretion of alpha1-antitrypsin and haptoglobin, and coexpression of the ubiquitination-resistant ERGIC3 variant largely restored their secretion, suggesting that MARCH2-mediated ERGIC3 ubiquitination is the major cause of the decrease in trafficking of ERGIC3-binding secretory proteins. | 31142615 |
| 2019-05-25 12:06:00 | Membrane-associated RING-CH (MARCH) 1 and 2 are MARCH family members that inhibit HIV-1 infection | 30630952 |
| 2018-05-12 11:03:00 | In this study, the authors found the expression of MARCH2 to be upregulated upon HIV-1 infection. MARCH2 inhibits the production and infection of HIV-1 through ligase activity-dependent envelope protein degradation and/or intracellular retention. | 29573664 |
| 2017-12-30 10:40:00 | MARCH2 has a role in regulating autophagy by promoting CFTR ubiquitination and degradation and PIK3CA-AKT-MTOR signaling | 27308891 |
| 2014-02-01 10:32:00 | Data indicate that E3 ubiquitin ligase MARCH2 co-immunoprecipitated and co-localized with CAL and syntaxin 6 (STX6), and show the ubiquitination of CFTR by MARCH2. | 23818989 |
| Type | IDs |
|---|---|
| Synonymous | HSPC240, MARCH-II, RNF172 |
| Gene |
UniProtKB-ID:
MARH2_HUMAN
UniprotKB:
Q9P0N8
UniParc:
UPI0000201FAC,
UPI0000070149
EMBL:
BC111388,
AF151074,
BC015910,
AB197929,
AC136469,
BC032624
Ensembl:
ENSG00000099785
KO:
hsa:51257
|
| Nucleutide sequences |
EMBL-CDS:
AAI11389.1,
AAF36160.1,
AAH32624.1,
AAH15910.1,
BAD89359.1
Gene_ORFName:
HSPC240
Ensembl_TRS:
ENST00000602117,
ENST00000381035,
ENST00000215555
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000471536,
ENSP00000370423,
ENSP00000215555
RefSeq:
NP_001005416.1,
NP_001356707.1,
NP_001356706.1,
NP_001005415.1,
NP_057580.3,
NP_001356708.1,
NP_001356705.1
|
| Others |
UniRef100:
UniRef100_Q9P0N8
UniRef90:
UniRef90_Q9P0N8
UniRef50:
UniRef50_Q9P0N8
UniGene:
Hs.631861
CCDS:
CCDS32894.1,
CCDS12202.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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