| Type | Description |
|---|---|
| Definition | proprotein convertase subtilisin/kexin type 5 |
| Date | Results | Publications |
|---|---|---|
| 2019-03-23 11:58:00 | this study demonstrates that Pcsk5 is expressed in bone-forming cells, and that OPN is a novel substrate for PC5/6 | 29126984 |
| 2017-07-08 12:42:00 | loss of the convertase furin or PC5/6 in hepatocytes results in a approximately 30% decrease in APC levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin activation. | 28468828 |
| 2016-02-27 11:01:00 | Case Report: whole exome sequencing of a case with the VACTERL association uncovered a novel frameshift mutation in the PCSK5 gene. | 26055999 |
| 2015-11-28 10:54:00 | full-length alpha-DG in the human endometrial epithelium is a barrier for embryo attachment and that removal of alpha-DG-N by proprotein convertase 5/6 (PC6; a protease critical for implantation | 26077903 |
| 2015-11-21 11:43:00 | Proprotein convertase 5/6 cleaves PDGFA in the human endometrium in preparation for embryo implantation. | 25429785 |
| Type | IDs |
|---|---|
| Synonymous | PC5, PC6, PC6A, SPC6 |
| Gene |
UniProtKB-ID:
PCSK5_HUMAN
UniprotKB:
Q92824
UniParc:
UPI0001DAD817,
UPI000006DF2E
EMBL:
U56387,
CH471089,
AL834522,
AL589653,
AL391868,
BC012064,
AK122718,
AL353607,
AL359253,
U49114
Ensembl:
ENSG00000099139
KO:
hsa:5125
|
| Nucleutide sequences |
EMBL-CDS:
EAW62575.1,
CAD39178.1,
AAH12064.1,
AAC50643.2,
AAA91807.1
Ensembl_TRS:
ENST00000376752,
ENST00000545128
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000365943,
ENSP00000446280
RefSeq:
XP_011517072.1,
XP_011517071.1,
NP_001358972.1,
XP_016870289.1,
NP_006191.2,
NP_001177411.1
|
| Others |
UniRef100:
UniRef100_Q92824
UniRef90:
UniRef90_Q92824
UniRef50:
UniRef50_Q92824
UniGene:
Hs.368542
CCDS:
CCDS55320.1,
CCDS6652.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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