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51231 VRK3

51231

VRK3

VRK serine/threonine kinase 3

protein-coding

Homo sapiens

基因描述

Type Description
Definition VRK serine/threonine kinase 3

研究结论

Date Results Publications
2020-02-01 11:34:00 VRK3 is an interesting and promising target in Diffuse intrinsic pontine glioma. 31324890
2018-06-09 10:12:00 Nuclear HSP70 leads to enhancement of vaccinia H1-related phosphatase (VHR) activity via protein-protein interaction rather than its molecular chaperone activity, thereby suppressing excessive ERK activation. Downregulation of either VRK3 or HSP70 rendered cells vulnerable to glutamate-induced apoptosis. 27941812
2018-06-02 11:46:00 this study not only provides a resource for investigating the unidentified functions of VRK1/VRK3, but also an insight into the regulatory roles of VRK1/VRK3 in biological processes. 28927264
2018-05-05 11:16:00 Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation 27346674
2017-06-24 11:36:00 Finally, downregulation of hvrk3 using siRNA reduced the amplitude and lengthened the period of the cellular bioluminescence rhythm. Taken together, these data suggest that VRK3 plays a role in setting the amplitude and period length of circadian rhythms in mammalian cells. 28412365

名称对应

Type IDs
Gene
UniProtKB-ID: VRK3_HUMAN, A0A024QZI4_HUMAN
UniprotKB: Q8IV63, A0A024QZI4
UniParc: UPI0000074692, UPI00003D1641, UPI0000035BA6
EMBL: AC011452, AF514788, AK303010, BC095449, BC023556, AB031052, AK292918, CH471177
Ensembl: ENSG00000105053
KO: hsa:51231
Nucleutide sequences
EMBL-CDS: AAP47180.1, AAH95449.1, BAG64141.1, AAH23556.1, BAF85607.1, BAA90769.1, EAW52590.1, EAW52588.1, EAW52591.1
Gene_ORFName: hCG_21106
Ensembl_TRS: ENST00000377011, ENST00000599538, ENST00000316763, ENST00000594948, ENST00000601341, ENST00000594092
Protein sequencees
Ensembl_PRO: ENSP00000472541, ENSP00000469880, ENSP00000366210, ENSP00000473171, ENSP00000324636, ENSP00000470156
RefSeq: NP_057524.3, XP_005259029.1, XP_006723300.1, NP_001020949.1, XP_006723301.1, NP_001295349.1, XP_005259028.1
Others
UniRef100: UniRef100_Q8IV63
UniRef90: UniRef90_Q8IV63
UniRef50: UniRef50_Q8IV63
UniGene: Hs.443330
CCDS: CCDS77334.1, CCDS33076.1, CCDS12791.1

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