| Type | Description |
|---|---|
| Definition | GPN-loop GTPase 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-22 11:17:00 | our analysis of public data revealed that Gpn3 overexpression was associated with a significant decrease in overall survival in patients with estrogen receptor-positive and Human epidermal growth factor receptor 2 (HER2+) breast cancer, supporting our proposal that targeting Gpn3 could potentially benefit patients with breast cancer. | 31431135 |
| 2017-12-16 10:31:00 | Results indicate that polyubiquitination on lysine 216 is a regulatory process for proteasomal degradation of Gpn3 that is not in a complex with Gpn1, a critical partner of Gpn3 in human cells. | 29029378 |
| 2017-11-25 15:41:00 | an acquired PDZ-binding motif in Gpn3 Q279* caused Gpn3 nuclear entry, and inhibited Gpn1 nuclear export and Gpn3-mediated RNAPII nuclear targeting. | 28940195 |
| 2015-01-24 11:31:00 | Gpn1-Gpn3 interaction was essential to maintain steady-state protein levels of both GTPases | 25241168 |
| 2011-12-17 11:59:00 | Data show that GPN1/GPN3 define a new family of small GTPases that are specialized for the transport of RNA polymerase II into the nucleus. | 21768307 |
| Type | IDs |
|---|---|
| Synonymous | ATPBD1C |
| Gene |
UniProtKB-ID:
GPN3_HUMAN
UniprotKB:
Q9UHW5
UniParc:
UPI00000411DE,
UPI00001FB1BF,
UPI0001B25F61
EMBL:
AM992619,
AY364262,
AK223209,
BC008416,
AM992620,
BC031024,
AY359078,
AC002350,
AK314946,
BX537973,
AF117229,
AC144548
Ensembl:
ENSG00000111231
KO:
hsa:51184
|
| Nucleutide sequences |
EMBL-CDS:
AAF17210.1,
BAG37451.1,
CAQ52400.1,
CAQ52399.1,
CAD97937.1,
AAH08416.1,
AAQ89437.1,
AAH31024.1,
BAD96929.1,
AAQ76821.1
Gene_ORFName:
UNQ1876/PRO4319,
AD-009
Ensembl_TRS:
ENST00000228827,
ENST00000537466,
ENST00000543199
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000442770,
ENSP00000443068,
ENSP00000228827
RefSeq:
XP_016874883.1,
NP_057385.3,
NP_001157844.1,
NP_001157845.1
|
| Others |
UniRef100:
UniRef100_Q9UHW5
UniRef90:
UniRef90_Q9UHW5
UniRef50:
UniRef50_Q9UHW5
UniGene:
Hs.634680
CCDS:
CCDS53830.1,
CCDS53831.1,
CCDS9147.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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