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5118 PCOLCE

5118

PCOLCE

procollagen C-endopeptidase enhancer

protein-coding

Homo sapiens

基因描述

Type Description
Definition procollagen C-endopeptidase enhancer

研究结论

Date Results Publications
2020-08-15 19:05:00 Up-regulation of PCOLCE by TWIST1 promotes metastasis in Osteosarcoma. 31285765
2020-02-15 13:06:00 PCPE-1 levels are elevated in chronic kidney disease patients and that this elevation associated with declining glomerular filtration rate. 30393914
2019-09-21 10:42:00 Study shows that the two CUB domains bind to two different chains of C-propeptide trimer of procollagen III (CPIII) and that the N-terminal region of one CPIII chain, close to the proteolytic cleavage site, lies in the cleft between CUB1 and CUB2. This suggests that enhancing activity involves unraveling of this chain from the rest of the trimer, thus facilitating the action of the proteinase involved. 30078642
2018-11-03 12:02:00 Serum PCPE-1 might be used as a noninvasive marker of liver fibrosis in chronic hepatitis B. 29683980
2015-09-26 20:29:00 Results suggest that PCPE-1 binding to syndecans and/or fibronectin may control collagen fibril assembly on the cell surface. 25286301

名称对应

Type IDs
Synonymous PCPE, PCPE-1, PCPE1
Gene
UniProtKB-ID: PCOC1_HUMAN
UniprotKB: Q15113
UniParc: UPI0000131428
EMBL: AK313748, AF053356, CH471091, AB008549, AF083655, BC000574, L33799, BC033205
Ensembl: ENSG00000106333
KO: hsa:5118
Nucleutide sequences
EMBL-CDS: AAA61949.1, AAD16041.1, AAH00574.1, AAH33205.1, EAW76515.1, BAG36488.1, BAA23281.1, AAC78800.1
Ensembl_TRS: ENST00000223061
Protein sequencees
Ensembl_PRO: ENSP00000223061
RefSeq: NP_002584.2, XP_024302553.1
Others
UniRef100: UniRef100_Q15113
UniRef90: UniRef90_Q15113
UniRef50: UniRef50_Q15113
UniGene: Hs.202097
CCDS: CCDS5700.1

全选

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研究热度

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