Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

Nat Metab     Michael Aregger , Keith A Lawson , Maximillian Billmann , Michael Costanzo , Amy H Y Tong , Katherine Chan , Mahfuzur Rahman , Kevin R Brown , Catherine Ross , Matej Usaj , Lucy Nedyalkova , Olga Sizova , Andrea Habsid , Judy Pawling , Zhen-Yuan Lin , Hala Abdouni , Cassandra J Wong , Alexander Weiss , Patricia Mero , James W Dennis , Anne-Claude Gingras , Chad L Myers , Brenda J Andrews , Charles Boone , Jason Moffat

Cytosolic localization of NADH cytochrome b5 oxidoreductase (Ncb5or).

FEBS Lett.     Veronika Zámbó , Mónika Tóth , Krisztina Schlachter , Péter Szelényi , Farkas Sarnyai , Gábor Lotz , Miklós Csala , Éva Kereszturi

Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase.

Biochimie     Fanni S Kálmán , Beáta Lizák , Szilvia K Nagy , Tamás Mészáros , Veronika Zámbó , József Mandl , Miklós Csala , Eva Kereszturi

Methemoglobin reductase deficiency: novel mutation is associated with a disease phenotype of intermediate severity.

J. Pediatr. Hematol. Oncol.     Melanie J Percy , Chris Barnes , Gemma Crighton , Richard J Leventer , Robert Wynn , Terence R Lappin

Charting the landscape of tandem BRCT domain-mediated protein interactions.

Sci Signal     Nicholas T Woods , Rafael D Mesquita , Michael Sweet , Marcelo A Carvalho , Xueli Li , Yun Liu , Huey Nguyen , C Eric Thomas , Edwin S Iversen , Sylvia Marsillac , Rachel Karchin , John Koomen , Alvaro N A Monteiro

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.

Brief. Bioinformatics     Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Diabetes Care     Swneke D Bailey , Changchun Xie , Ron Do , Alexandre Montpetit , Rafael Diaz , Viswanathan Mohan , Bernard Keavney , Salim Yusuf , Hertzel C Gerstein , James C Engert , Sonia Anand , DREAM investigators

Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain.

J Biol Chem     Bin Deng , Sudharsan Parthasarathy , WenFang Wang , Brian R Gibney , Kevin P Battaile , Scott Lovell , David R Benson , Hao Zhu

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Am. J. Hum. Genet.     Philippa J Talmud , Fotios Drenos , Sonia Shah , Tina Shah , Jutta Palmen , Claudio Verzilli , Tom R Gaunt , Jacky Pallas , Ruth Lovering , Kawah Li , Juan Pablo Casas , Reecha Sofat , Meena Kumari , Santiago Rodriguez , Toby Johnson , Stephen J Newhouse , Anna Dominiczak , Nilesh J Samani , Mark Caulfield , Peter Sever , Alice Stanton , Denis C Shields , Sandosh Padmanabhan , Olle Melander , Claire Hastie , Christian Delles , Shah Ebrahim , Michael G Marmot , George Davey Smith , Debbie A Lawlor , Patricia B Munroe , Ian N Day , Mika Kivimaki , John Whittaker , Steve E Humphries , Aroon D Hingorani , ASCOT investigators , NORDIL investigators , BRIGHT Consortium

Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

Genome Res.     Kouichi Kimura , Ai Wakamatsu , Yutaka Suzuki , Toshio Ota , Tetsuo Nishikawa , Riu Yamashita , Jun-ichi Yamamoto , Mitsuo Sekine , Katsuki Tsuritani , Hiroyuki Wakaguri , Shizuko Ishii , Tomoyasu Sugiyama , Kaoru Saito , Yuko Isono , Ryotaro Irie , Norihiro Kushida , Takahiro Yoneyama , Rie Otsuka , Katsuhiro Kanda , Takahide Yokoi , Hiroshi Kondo , Masako Wagatsuma , Katsuji Murakawa , Shinichi Ishida , Tadashi Ishibashi , Asako Takahashi-Fujii , Tomoo Tanase , Keiichi Nagai , Hisashi Kikuchi , Kenta Nakai , Takao Isogai , Sumio Sugano