| Type | Description |
|---|---|
| Definition | hydroxysteroid 17-beta dehydrogenase 12 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:42:00 | An Integrative Phenotype-Genotype Approach Using Phenotypic Characteristics from the UAE National Diabetes Study Identifies HSD17B12 as a for Obesity and Type 2 Diabetes. | 32340285 |
| 2020-11-21 13:34:00 | Very-long-chain fatty acid metabolic capacity of 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) promotes replication of hepatitis C virus and related flaviviruses. | 32132633 |
| 2020-04-18 10:04:00 | Silencing of hydroxysteroid 17-beta dehydrogenase 12 essentially catalyzes the 3-ketoacyl-CoA reduction step in long-chain fatty acids production, modulates proliferation and migration of breast cancer cells in a cell line-dependent manner. | 31302749 |
| 2020-02-22 10:57:00 | Study identified two independent SNPs of ELOVL2 rs3734398 T>C and HSD17B12 rs11037684 A>G that predicted cutaneous melanoma disease-specific survival. The ELOVL2 rs3734398 variant CC genotype was found to be associated with a significantly increased mRNA expression level. | 30734280 |
| 2019-11-23 10:17:00 | Among lung-expressing enzymes only HSD17beta12 exhibited activity against tobacco-specific carcinogen nitrosamine NNK. siRNA knock-down of HSD17beta12 resulted in significant decreases in (R)-NNAL-formation activity in HEK293 cells. These data suggest that both cytosolic and microsomal enzymes are active against NNK and that HSD17beta12 is the major active microsomal reductase that contributes to (R)-NNAL formation in ... | 29788210 |
| Type | IDs |
|---|---|
| Synonymous | KAR, SDR12C1 |
| Gene |
UniProtKB-ID:
DHB12_HUMAN
UniprotKB:
Q53GQ0
UniParc:
UPI000004C79B,
UPI00000733D7
EMBL:
AK075216,
BC012043,
AK027882,
AC068205,
AF078850,
CH471064,
AK074952,
BC012536,
AK292625,
AC087521,
AK222881,
AC023085
Ensembl:
ENSG00000149084
KO:
hsa:51144
|
| Nucleutide sequences |
EMBL-CDS:
AAH12043.1,
BAF85314.1,
EAW68088.1,
EAW68082.1,
BAD96601.1,
EAW68087.1,
AAD44482.1,
AAH12536.1,
BAG52039.1,
BAG52086.1
Ensembl_TRS:
ENST00000278353,
ENST00000395700
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000379052,
ENSP00000278353
RefSeq:
NP_057226.1,
XP_024304340.1,
XP_024304339.1,
XP_011518458.1,
XP_016873370.1,
XP_024304341.1
|
| Others |
UniRef100:
UniRef100_Q53GQ0
UniRef90:
UniRef90_Q53GQ0
UniRef50:
UniRef50_Q53GQ0
UniGene:
Hs.132513
CCDS:
CCDS7905.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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