| Type | Description |
|---|---|
| Definition | aph-1 homolog A, gamma-secretase subunit |
| Date | Results | Publications |
|---|---|---|
| 2017-08-12 10:27:00 | Using purified PSEN1/Aph1A gamma-secretase and the APPC99-3XFLAG substrate, authors show that substrate shortening progressively destabilizes the consecutive enzyme-substrate complexes that characterize the sequential gamma-secretase processing of APP; present a unifying model for how PSEN or APP mutations enhance amyloidogenic Abeta production, suggests that environmental factors may increase Alzheimer's Disease risk. | 28753424 |
| 2017-06-24 12:23:00 | Data show that presenilin 1 (PS1)/anterior-pharynx-defective protein 1 (Aph1b), presenilin 2 (PS2)/Aph1aL, PS2/Aph1aS and PS2/anterior pharynx defective 1 homolog B (Aph1b) gamma-secretase produced amyloid beta peptide (Abeta) with a higher Abeta42+Abeta43-to-Abeta40 (Abeta42(43)/Abeta40) ratio than the other gamma-secretases. | 27608597 |
| 2016-12-17 11:48:00 | Data show that presenilin 1 (PS1)-containing gamma-secretase complexes were targeted to the plasma membrane, whereas presenilin 2 (PS2)-containing ones were addressed to the trans-Golgi network, to recycling endosomes. | 27059953 |
| 2016-02-13 10:45:00 | No statistically significant difference was detected either in APOE or APH-1a polymorphisms, not suggesting a strong susceptibility to the development of Alzheimer disease. | 26738354 |
| 2015-08-08 10:35:00 | analysis of how the conformation of presenilin, Pen-2, Aph-1, and nicastrin affect the function and mechanism of gamma-secretase | 25918421 |
| Type | IDs |
|---|---|
| Synonymous | 6530402N02Rik, APH-1, APH-1A, CGI-78 |
| Gene |
UniProtKB-ID:
APH1A_HUMAN,
B4DUG7_HUMAN
UniprotKB:
Q96BI3,
B4DUG7
UniParc:
UPI0000048EEC,
UPI0000204179,
UPI0000073CA3,
UPI00017A775B
EMBL:
AK298832,
BC008732,
BC020590,
AK300640,
BC009501,
AF151835,
CH471121,
BC017699,
AY113699,
AF508787,
AL138795,
BC015568,
AY113698,
AY358951,
AK027879,
AK075295,
BC001230
Ensembl:
ENSG00000117362
KO:
hsa:51107
|
| Nucleutide sequences |
EMBL-CDS:
AAN63816.1,
BAG60962.1,
BAC11529.1,
EAW53565.1,
CAI22812.1,
AAH09501.1,
AAH08732.1,
AAQ89310.1,
AAH17699.1,
AAM61956.1,
AAH01230.1,
CAI22811.1,
EAW53566.1,
AAM61955.1,
BAG51389.1,
AAH15568.1,
EAW53567.1,
AAH20590.1,
AAD34072.1,
BAG62329.1
Gene_ORFName:
UNQ579/PRO1141,
CGI-78
Ensembl_TRS:
ENST00000360244,
ENST00000414276,
ENST00000369109
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000358105,
ENSP00000397473,
ENSP00000353380
RefSeq:
XP_024303223.1,
XP_016856906.1,
NP_001230701.1,
NP_057106.2,
NP_001071096.1,
NP_001230700.1
|
| Others |
UniRef100:
UniRef100_Q96BI3,
UniRef100_B4DUG7
UniRef90:
UniRef90_Q96BI3,
UniRef90_A0A337S3U0
UniRef50:
UniRef50_Q96BI3,
UniRef50_F7ADK5
UniGene:
Hs.108408,
Hs.735911
CCDS:
CCDS58025.1,
CCDS41391.1,
CCDS41390.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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