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51105 PHF20L1

51105

PHF20L1

PHD finger protein 20 like 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition PHD finger protein 20 like 1

研究结论

Date Results Publications
2019-06-15 11:09:00 associates with SOX2, antagonizes SOX2 ubiquitination and the sequential degradation induced by the MLL1/WDR5 complexes 30089852
2019-01-12 10:52:00 Data suggest that, in human ovarian teratocarcinoma cell line, methylation-dependent proteolysis of SOX2 is controlled by LSD1 and PHF20L1 via regulation of SET7 activity; these data are consistent with previous studies in mouse primary stem cells. (SOX2 = SRY-box 2 transcription factor; LSD1 = lysine demethylase-1A; PHF20L1 = PHD finger protein 20 like-1; SET7 = histone-lysine N-methyltransferase SETD7) 29358331
2018-07-28 10:06:00 Authors find that the interplay between PHF20L1 and mono-methyl pRb is important for maintaining the integrity of a pRb-dependent G1-S-phase checkpoint. Results highlight the distinct roles that methyl-lysine readers have in regulating the biological activity of pRb. 28841214
2016-10-29 11:01:00 results demonstrated the oncogenic potential of PHF20L1 and its association with poor prognostic parameters in breast cancer. 26588862
2014-05-31 10:29:00 Malignant brain tumor domain of PHF20L1 reads and controls enzyme levels of methylated DNMT1 in cells, thus representing a novel antagonist of DNMT1 degradation. 24492612

名称对应

Type IDs
Synonymous CGI-72, TDRD20B, URLC1
Gene
UniProtKB-ID: P20L1_HUMAN, A0A0A0MQS0_HUMAN, Q9H8G4_HUMAN, A0A0A8K9A6_HUMAN
UniprotKB: A8MW92, A0A0A0MQS0, Q9H8G4, A0A0A8K9A6
UniParc: UPI000006F559, UPI0000231C85, UPI0000072342, UPI0000DBD7AF, UPI00015E02FB
EMBL: BC015211, AY279109, BC056413, AK025268, AF228727, AK023711, CH471060, AB101203, AF151830, KF510134, BC050655, AK290506, AF230666
Ensembl: ENSG00000129292
KO: hsa:51105
Nucleutide sequences
EMBL-CDS: BAB15098.1, AAP33690.1, EAW92152.1, AAH56413.2, EAW92148.1, BAF83195.1, AAD34067.1, AAH15211.1, AAH50655.4, BAB14653.1, BAQ19747.1
Gene_ORFName: CGI-72
Ensembl_TRS: ENST00000337920, ENST00000622263, ENST00000395386, ENST00000220847
Protein sequencees
Ensembl_PRO: ENSP00000338269, ENSP00000482945, ENSP00000378784, ENSP00000220847
RefSeq: XP_016869006.1, XP_011515377.1, XP_011515383.1, XP_016868999.1, NP_057102.4, XP_011515378.1, NP_940915.1, XP_011515390.1, NP_001264125.1, XP_011515380.1, XP_016869002.1, NP_001349900.1, XP_016868998.1, XP_016869000.1, XP_005250988.1, XP_011515381.1, XP_011515382.1, XP_016869003.1, XP_011515379.1, XP_016869005.1
Others
UniRef100: UniRef100_A8MW92, UniRef100_A0A0A0MQS0, UniRef100_Q9H8G4, UniRef100_A0A0A8K9A6
UniRef90: UniRef90_A8MW92, UniRef90_G3SIU6, UniRef90_Q9H8G4
UniRef50: UniRef50_Q9H8G4, UniRef50_Q8CCJ9, UniRef50_Q8CCJ9-1
UniGene: Hs.304362
CCDS: CCDS6368.1, CCDS6367.2

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