| Type | Description |
|---|---|
| Definition | glutaredoxin 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 10:15:00 | By sensing the overall cellular redox conditions, mitochondrial Grx2 dimers become active monomers upon oxidative stress induced by sodium selenite with the consequent release of the iron-sulfur cluster, leading to activation of the intrinsic apoptotic pathway. | 31168542 |
| 2018-07-21 12:10:00 | GRX2 is important in the control of cardiac mitochondrial structure and function, and protects against human cardiac pathologies. | 29101900 |
| 2018-04-14 10:41:00 | Study shows that Grx2 detoxifies *NO in mature oligodendrocytes and oligodendroglial precursor cellsvia the formation of dinitrosyl-iron-complexes, inhibiting the formation of harmful peroxynitrite and reducing subsequent oligodendroglial damage. Findings link inorganic biochemistry to neuroinflammation and identify glutaredoxin 2 as a protective factor against neuroinflammation-mediated myelin damage. | 28618115 |
| 2015-09-05 10:45:00 | Grx2 and Trx1 contribute significantly to neuronal integrity and could be clinically relevant in neuronal damage following perinatal asphyxia and other neuronal disorders. | 25735211 |
| 2015-04-25 12:11:00 | The Grx2 system could help to keep Trx2/1 reduced during an oxidative stress, thereby contributing to the anti-apoptotic signaling. | 24295294 |
| Type | IDs |
|---|---|
| Synonymous | CGI-133, GRX2 |
| Gene |
UniProtKB-ID:
GLRX2_HUMAN
UniprotKB:
Q9NS18
UniParc:
UPI000006FC67,
UPI000006F2AD
EMBL:
BC028113,
AF290514,
AF132495,
AF151891,
DQ194815,
AL136370,
AY038988
Ensembl:
ENSG00000023572
KO:
hsa:51022
|
| Nucleutide sequences |
EMBL-CDS:
AAH28113.1,
AAD34128.1,
AAK83089.1,
AAK72499.1,
AAF37320.2,
ABA03170.1
Gene_ORFName:
CGI-133
Ensembl_TRS:
ENST00000367440,
ENST00000367439,
ENST00000608166
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000356409,
ENSP00000494652,
ENSP00000356410
RefSeq:
NP_932066.1,
NP_057150.2,
NP_001230328.1
|
| Others |
UniRef100:
UniRef100_Q9NS18
UniRef90:
UniRef90_Q9NS18
UniRef50:
UniRef50_Q9NS18
UniGene:
Hs.458283
CCDS:
CCDS1380.1,
CCDS1381.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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