| Type | Description |
|---|---|
| Definition | derlin 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-05-04 11:41:00 | Derlin-2 is part of a protein quality control mechanism that can rescue glomerular injury attributable to impaired protein folding pathways in the endoplasmic reticulum. | 29167172 |
| 2016-04-02 10:04:00 | specific silencing of Derlin-2, p97 and HRD1 by shRNAs increases steady state levels of proinsulin. these ERAD constituents are critically involved in proinsulin degradation and may therefore also play a role in subsequent antigen generation. | 26107514 |
| 2013-12-14 10:47:00 | derlin2 functions with HRD1 in ERAD of certain substrates independent of their glycosylation status. | 23867461 |
| 2010-01-21 00:00:00 | Findings indicate that Derlin-2 provides the missing link between EDEM and p97 in the process of degrading misfolded glycoproteins. | 16449189 |
| 2010-01-21 00:00:00 | Required for Polyoma virus infection. | 16912321 |
| Type | IDs |
|---|---|
| Synonymous | CGI-101, DERtrin-2, F-LAN-1, F-LANa, FLANa, derlin-2 |
| Gene |
UniProtKB-ID:
DERL2_HUMAN,
I3L3R8_HUMAN
UniprotKB:
Q9GZP9,
I3L3R8
UniParc:
UPI0000071535,
UPI0000E59DE1
EMBL:
AC004148,
CR457202,
AF151859,
AF208065,
BC010890,
AF132289,
AF242523
Ensembl:
ENSG00000072849
KO:
hsa:51009
|
| Nucleutide sequences |
EMBL-CDS:
AAG43049.1,
AAH10890.1,
AAD34096.1,
AAL14869.1,
CAG33483.1,
AAF99603.1
Gene_ORFName:
SBBI53,
CGI-101
Ensembl_TRS:
ENST00000158771,
ENST00000572834
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000158771,
ENSP00000460671
RefSeq:
NP_057125.2,
NP_001291706.1,
NP_001291708.1
|
| Others |
UniRef100:
UniRef100_Q9GZP9,
UniRef100_I3L3R8
UniRef90:
UniRef90_I3L3R8,
UniRef90_Q9GZP9
UniRef50:
UniRef50_I3L3R8,
UniRef50_Q9GZP9
UniGene:
Hs.286131
CCDS:
CCDS11073.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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