| Type | Description |
|---|---|
| Definition | protocadherin 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-05-25 12:15:00 | identification of the human asthma-associated gene protocadherin-1 as an essential determinant of entry and infection in pulmonary endothelial cells by two hantaviruses that cause hantavirus pulmonary syndrome, Andes virus and Sin Nombre virus; the surface glycoproteins of ANDV and SNV directly recognize the outermost extracellular repeat domain of PCDH1-a member of the cadherin superfamily--to exploit PCDH1 for entry | 30464266 |
| 2017-06-24 12:47:00 | Results show that PCDH1 is localized to the cell membrane of bronchial epithelial cells basolateral to the adherens junction. Its expression is not reduced nor delocalized in asthma even though PCDH1 contributes to homotypic adhesion, epithelial barrier formation and repair. | 27701444 |
| 2016-03-19 10:19:00 | PCDH1 is important for airway function as a physical barrier, and its dysfunction is involved in the pathogenesis of allergic airway inflammation. | 26227965 |
| 2016-01-16 10:31:00 | PCDH1 and SMAD3 act in a single pathway in asthma susceptibility that affects sensitivity of the airway epithelium to TGF-beta. | 26209277 |
| 2014-11-08 13:40:00 | Common variations in PCDH1 increase the risk of developing both transient early asthma and atopic dermatitis in early childhood | 23988763 |
| Type | IDs |
|---|---|
| Synonymous | PC42, PCDH42 |
| Gene |
UniProtKB-ID:
PCDH1_HUMAN,
B4DUA8_HUMAN,
B4E2D8_HUMAN,
A8K0E7_HUMAN
UniprotKB:
Q08174,
B4DUA8,
B4E2D8,
A8K0E7
UniParc:
UPI00015DA4C7,
UPI00017A7DE3,
UPI000016158F,
UPI0000074735,
UPI00017A8781
EMBL:
AK289512,
AK300564,
BC035812,
CH471062,
L11370,
AC094107,
AK304231,
L11369
Ensembl:
ENSG00000156453
KO:
hsa:5097
|
| Nucleutide sequences |
EMBL-CDS:
AAH35812.1,
EAW61902.1,
AAA36418.1,
AAA36419.1,
BAG62270.1,
BAG65100.1,
BAF82201.1
Ensembl_TRS:
ENST00000287008,
ENST00000394536
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000287008,
ENSP00000378043
RefSeq:
NP_001265544.1,
XP_016865006.1,
NP_115796.2,
XP_005268511.2,
XP_016865007.1,
XP_005268512.1,
NP_001265542.1,
XP_005268509.2,
NP_002578.2
|
| Others |
UniRef100:
UniRef100_Q08174,
UniRef100_B4E2D8,
UniRef100_B4DUA8,
UniRef100_A8K0E7
UniRef90:
UniRef90_Q08174,
UniRef90_B4DUA8,
UniRef90_Q8CFX3
UniRef50:
UniRef50_Q8CFX3,
UniRef50_Q08174,
UniRef50_G3HYD5
UniGene:
Hs.79769
CCDS:
CCDS43375.1,
CCDS4267.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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