| Type | Description |
|---|---|
| Definition | SH3 and multiple ankyrin repeat domains 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-18 10:12:00 | SH3 and multiple ankyrin repeat domains protein (SHANK) family includes the three multidomain structural proteins (SHANK1, SHANK2, and SHANK3) that enrich in excitatory glutamatergic synapses in mammalian brain. | 30629339 |
| 2018-12-01 12:24:00 | Authors summarize and discuss behavioral and neuronal findings obtained in the Shank1 knockout mouse model for Autism spectrum disorder (ASD); identify open research questions by comparing such findings with the symptoms present in humans diagnosed with ASD and carrying SHANK1 deletions; conclude by discussing the implications of the behavioral and neuronal phenotypes displayed by the Shank1 knockout mouse model. | 28963042 |
| 2017-06-24 10:57:00 | SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN domain and thus limiting their bioavailability at the plasma membrane. | 28263956 |
| 2015-10-31 10:53:00 | Data show that the Shank1 protein mRNA adopts two very stable intramolecular G-quadruplexes which are bound specifically and with high affinity by X mental retardation protein (FMRP). | 25692235 |
| 2015-01-10 13:35:00 | a non-canonical initiation site is required for efficient translation of the dendritically localized Shank1 mRNA | 24533096 |
| Type | IDs |
|---|---|
| Synonymous | SPANK-1, SSTRIP, synamon |
| Gene |
UniProtKB-ID:
SHAN1_HUMAN,
H9KV90_HUMAN
UniprotKB:
Q9Y566,
H9KV90
UniParc:
UPI000013E109,
UPI000059D76D,
UPI0000202A3B,
UPI0000E5A22E
EMBL:
AF163302,
AC010325,
AC008743,
AF226728
Ensembl:
ENSG00000161681
KO:
hsa:50944
|
| Nucleutide sequences |
EMBL-CDS:
AAD45121.1,
AAF35887.1
Ensembl_TRS:
ENST00000391813,
ENST00000359082,
ENST00000293441,
ENST00000391814
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000351984,
ENSP00000293441,
ENSP00000375689,
ENSP00000375690
RefSeq:
NP_057232.2,
XP_011525316.1,
XP_011525315.1
|
| Others |
UniRef100:
UniRef100_H9KV90,
UniRef100_Q9Y566
UniRef90:
UniRef90_Q9Y566
UniRef50:
UniRef50_Q9WV48
UniGene:
Hs.274255
CCDS:
CCDS12799.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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