| Type | Description |
|---|---|
| Definition | phosphodiesterase 11A |
| Date | Results | Publications |
|---|---|---|
| 2016-09-24 11:34:00 | One percent of the Swedish population carries a PDE11A loss-of-function mutation which is associated with elevated BP, abdominal obesity, and risk of ischemic stroke. | 26820475 |
| 2016-07-16 10:04:00 | Testicular germ cell tumors had 55 PDE11A variants: 20 missense (10 new, 9 in transcript variant 4, 1 in transcript variant 3), 4 splice-site, 2 nonsense, 7 synonymous, and 22 intronic. p.F258Y, p.G291R, p.V820M, p.R545X, and p.K568R were only in cases. | 26459559 |
| 2013-01-26 10:19:00 | PDE11A genetic variants may increase predisposition to ACTH-independent macronodular adrenal hyperplasia. | 22996146 |
| 2012-01-21 11:41:00 | found in single nerve trunks in the clitoral stroma | 21697861 |
| 2011-02-05 11:42:00 | Our data suggest that, like in the adrenal cortex and the testicular germ cells, PDE11A-inactivating genetic alterations may play a role in susceptibility to prostate cancer | 20881257 |
| Type | IDs |
|---|---|
| Synonymous | PPNAD2 |
| Gene |
UniProtKB-ID:
PDE11_HUMAN
UniprotKB:
Q9HCR9
UniParc:
UPI0000209162,
UPI0000E5D21A,
UPI00001402CB,
UPI00001402C1
EMBL:
BC114431,
AJ251509,
AC073834,
AJ278682,
AC073892,
AC083824,
AF281865,
AB036704,
AC012499,
AC011998,
BC112393,
AB048423,
AB038041
Ensembl:
ENSG00000128655
KO:
hsa:50940
|
| Nucleutide sequences |
EMBL-CDS:
CAB82573.1,
AAG32023.1,
BAB62713.2,
AAI14432.1,
BAB62712.1,
AAY14803.1,
AAI12394.1,
BAB16371.1,
BAB16372.1,
CAC15567.1,
BAB62714.1
Ensembl_TRS:
ENST00000409504,
ENST00000389683,
ENST00000286063
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000374333,
ENSP00000386539,
ENSP00000286063
RefSeq:
NP_001070664.1,
NP_058649.3,
NP_001070826.1,
NP_001070665.1
|
| Others |
UniRef100:
UniRef100_Q9HCR9
UniRef90:
UniRef90_Q9HCR9
UniRef50:
UniRef50_Q9HCR9
UniGene:
Hs.570273
CCDS:
CCDS42786.1,
CCDS33334.1,
CCDS46459.1,
CCDS42785.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 26820475 |
J. Hypertens. Therese Ohlsson , Arne Lindgren , Gunnar Engström , Christina Jern , Olle Melander |
2016-03-01 | - |
| 26459559 |
Rare inactivating PDE11A variants associated with testicular germ cell tumors. Endocr. Relat. Cancer Anand Pathak , Douglas R Stewart , Fabio R Faucz , Paraskevi Xekouki , Sara Bass , Aurelie Vogt , Xijun Zhang , Joseph Boland , Meredith Yeager , Jennifer T Loud , Katherine L Nathanson , Katherine A McGlynn , Constantine A Stratakis , Mark H Greene , Lisa Mirabello |
2015-12-01 | - |
| 23583979 |
Nat. Genet. Marcel den Hoed , Mark Eijgelsheim , Tõnu Esko , Bianca J J M Brundel , David S Peal , David M Evans , Ilja M Nolte , Ayellet V Segrè , Hilma Holm , Robert E Handsaker , Harm-Jan Westra , Toby Johnson , Aaron Isaacs , Jian Yang , Alicia Lundby , Jing Hua Zhao , Young Jin Kim , Min Jin Go , Peter Almgren , Murielle Bochud , Gabrielle Boucher , Marilyn C Cornelis , Daniel Gudbjartsson , David Hadley , Pim van der Harst , Caroline Hayward , Martin den Heijer , Wilmar Igl , Anne U Jackson , Zoltán Kutalik , Jian'an Luan , John P Kemp , Kati Kristiansson , Claes Ladenvall , Mattias Lorentzon , May E Montasser , Omer T Njajou , Paul F O'Reilly , Sandosh Padmanabhan , Beate St Pourcain , Tuomo Rankinen , Perttu Salo , Toshiko Tanaka , Nicholas J Timpson , Veronique Vitart , Lindsay Waite , William Wheeler , Weihua Zhang , Harmen H M Draisma , Mary F Feitosa , Kathleen F Kerr , Penelope A Lind , Evelin Mihailov , N Charlotte Onland-Moret , Ci Song , Michael N Weedon , Weijia Xie , Loic Yengo , Devin Absher , Christine M Albert , Alvaro Alonso , Dan E Arking , Paul I W de Bakker , Beverley Balkau , Cristina Barlassina , Paola Benaglio , Joshua C Bis , Nabila Bouatia-Naji , Søren Brage , Stephen J Chanock , Peter S Chines , Mina Chung , Dawood Darbar , Christian Dina , Marcus Dörr , Paul Elliott , Stephan B Felix , Krista Fischer , Christian Fuchsberger , Eco J C de Geus , Philippe Goyette , Vilmundur Gudnason , Tamara B Harris , Anna-Liisa Hartikainen , Aki S Havulinna , Susan R Heckbert , Andrew A Hicks , Albert Hofman , Suzanne Holewijn , Femke Hoogstra-Berends , Jouke-Jan Hottenga , Majken K Jensen , Asa Johansson , Juhani Junttila , Stefan Kääb , Bart Kanon , Shamika Ketkar , Kay-Tee Khaw , Joshua W Knowles , Angrad S Kooner , Jan A Kors , Meena Kumari , Lili Milani , Päivi Laiho , Edward G Lakatta , Claudia Langenberg , Maarten Leusink , Yongmei Liu , Robert N Luben , Kathryn L Lunetta , Stacey N Lynch , Marcello R P Markus , Pedro Marques-Vidal , Irene Mateo Leach , Wendy L McArdle , Steven A McCarroll , Sarah E Medland , Kathryn A Miller , Grant W Montgomery , Alanna C Morrison , Martina Müller-Nurasyid , Pau Navarro , Mari Nelis , Jeffrey R O'Connell , Christopher J O'Donnell , Ken K Ong , Anne B Newman , Annette Peters , Ozren Polasek , Anneli Pouta , Peter P Pramstaller , Bruce M Psaty , Dabeeru C Rao , Susan M Ring , Elizabeth J Rossin , Diana Rudan , Serena Sanna , Robert A Scott , Jaban S Sehmi , Stephen Sharp , Jordan T Shin , Andrew B Singleton , Albert V Smith , Nicole Soranzo , Tim D Spector , Chip Stewart , Heather M Stringham , Kirill V Tarasov , André G Uitterlinden , Liesbeth Vandenput , Shih-Jen Hwang , John B Whitfield , Cisca Wijmenga , Sarah H Wild , Gonneke Willemsen , James F Wilson , Jacqueline C M Witteman , Andrew Wong , Quenna Wong , Yalda Jamshidi , Paavo Zitting , Jolanda M A Boer , Dorret I Boomsma , Ingrid B Borecki , Cornelia M van Duijn , Ulf Ekelund , Nita G Forouhi , Philippe Froguel , Aroon Hingorani , Erik Ingelsson , Mika Kivimaki , Richard A Kronmal , Diana Kuh , Lars Lind , Nicholas G Martin , Ben A Oostra , Nancy L Pedersen , Thomas Quertermous , Jerome I Rotter , Yvonne T van der Schouw , W M Monique Verschuren , Mark Walker , Demetrius Albanes , David O Arnar , Themistocles L Assimes , Stefania Bandinelli , Michael Boehnke , Rudolf A de Boer , Claude Bouchard , W L Mark Caulfield , John C Chambers , Gary Curhan , Daniele Cusi , Johan Eriksson , Luigi Ferrucci , Wiek H van Gilst , Nicola Glorioso , Jacqueline de Graaf , Leif Groop , Ulf Gyllensten , Wen-Chi Hsueh , Frank B Hu , Heikki V Huikuri , David J Hunter , Carlos Iribarren , Bo Isomaa , Marjo-Riitta Jarvelin , Antti Jula , Mika Kähönen , Lambertus A Kiemeney , Melanie M van der Klauw , Jaspal S Kooner , Peter Kraft , Licia Iacoviello , Terho Lehtimäki , Marja-Liisa L Lokki , Braxton D Mitchell , Gerjan Navis , Markku S Nieminen , Claes Ohlsson , Neil R Poulter , Lu Qi , Olli T Raitakari , Eric B Rimm , John D Rioux , Federica Rizzi , Igor Rudan , Veikko Salomaa , Peter S Sever , Denis C Shields , Alan R Shuldiner , Juha Sinisalo , Alice V Stanton , Ronald P Stolk , David P Strachan , Jean-Claude Tardif , Unnur Thorsteinsdottir , Jaako Tuomilehto , Dirk J van Veldhuisen , Jarmo Virtamo , Jorma Viikari , Peter Vollenweider , Gérard Waeber , Elisabeth Widen , Yoon Shin Cho , Jesper V Olsen , Peter M Visscher , Cristen Willer , Lude Franke , Global BPgen Consortium , CARDIoGRAM Consortium , Jeanette Erdmann , John R Thompson , PR GWAS Consortium , Arne Pfeufer , QRS GWAS Consortium , Nona Sotoodehnia , QT-IGC Consortium , Christopher Newton-Cheh , CHARGE-AF Consortium , Patrick T Ellinor , Bruno H Ch Stricker , Andres Metspalu , Markus Perola , Jacques S Beckmann , George Davey Smith , Kari Stefansson , Nicholas J Wareham , Patricia B Munroe , Ody C M Sibon , David J Milan , Harold Snieder , Nilesh J Samani , Ruth J F Loos |
2013-06-01 | - |
| 22996146 |
J. Clin. Endocrinol. Metab. Delphine Vezzosi , Rossella Libé , Camille Baudry , Marthe Rizk-Rabin , Anelia Horvath , Isaac Levy , Fernande René-Corail , Bruno Ragazzon , Constantine A Stratakis , Grégoire Vandecasteele , Jérôme Bertherat |
2012-11-01 |
PDE11A
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21697861 |
Int. J. Impot. Res. S Ãckert , M Oelke , K Albrecht , D Breitmeier , M A Kuczyk , P Hedlund |
2011-06-23 |
PDE11A,
PDE2A,
PRKG1,
PDE5A
|
| 20351714 |
Mol. Psychiatry F J Bosker , C A Hartman , I M Nolte , B P Prins , P Terpstra , D Posthuma , T van Veen , G Willemsen , R H DeRijk , E J de Geus , W J Hoogendijk , P F Sullivan , B W Penninx , D I Boomsma , H Snieder , W A Nolen |
2011-05-01 |
PDE10A,
CHRM2,
COMT,
CRHBP,
CRHR1,
CRHR2,
DCANP1,
CYP2C9,
ACE,
DRD1,
DRD2,
DRD3,
DRD4,
AGTR1,
ESR1,
ESR2,
ACSL4,
GABRA3,
DISC1,
GNB3,
NR3C1,
HP,
HTR1A,
HTR2A,
HTR2C,
APOE,
AR,
M6PR,
MAOA,
MTHFR,
NGFR,
NPY,
P2RX7,
PAM,
PDE11A,
GMIP,
PDE2A,
PDE6C,
PDE9A,
PLA2G4A,
AVPR1B,
BCR,
BDNF,
CCL2,
SLC6A2,
SLC6A4,
PDE5A,
CCKAR,
CHRFAM7A,
HTR3B,
GPR50
|
| 21047926 |
J Clin Endocrinol Metab Rossella Libé , Anelia Horvath , Delphine Vezzosi , Amato Fratticci , Joel Coste , Karine Perlemoine , Bruno Ragazzon , Marine Guillaud-Bataille , Lionel Groussin , Eric Clauser , Marie-Laure Raffin-Sanson , Jennifer Siegel , Jason Moran , Limor Drori-Herishanu , Fabio Rueda Faucz , Maya Lodish , Maria Nesterova , Xavier Bertagna , Jerome Bertherat , Constantine A Stratakis |
2011-01-01 | - |
| 20881257 |
Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer. J Clin Endocrinol Metab Fabio Rueda Faucz , Anelia Horvath , Anya Rothenbuhler , Madson Q Almeida , Rossella Libé , Marie-Laure Raffin-Sanson , Jerome Bertherat , Dirce Maria Carraro , Fernando Augusto Soares , Gustavo de Campos Molina , Antonio H Campos , Rodrigo B Alexandre , Marcelo Luiz Bendhack , Maria Nesterova , Constantine A Stratakis |
2011-01-01 | - |
| 20881960 |
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature Hana Lango Allen , Karol Estrada , Guillaume Lettre , Sonja I Berndt , Michael N Weedon , Fernando Rivadeneira , Cristen J Willer , Anne U Jackson , Sailaja Vedantam , Soumya Raychaudhuri , Teresa Ferreira , Andrew R Wood , Robert J Weyant , Ayellet V Segrè , Elizabeth K Speliotes , Eleanor Wheeler , Nicole Soranzo , Ju-Hyun Park , Jian Yang , Daniel Gudbjartsson , Nancy L Heard-Costa , Joshua C Randall , Lu Qi , Albert Vernon Smith , Reedik Mägi , Tomi Pastinen , Liming Liang , Iris M Heid , Jian'an Luan , Gudmar Thorleifsson , Thomas W Winkler , Michael E Goddard , Ken Sin Lo , Cameron Palmer , Tsegaselassie Workalemahu , Yurii S Aulchenko , Asa Johansson , M Carola Zillikens , Mary F Feitosa , Tõnu Esko , Toby Johnson , Shamika Ketkar , Peter Kraft , Massimo Mangino , Inga Prokopenko , Devin Absher , Eva Albrecht , Florian Ernst , Nicole L Glazer , Caroline Hayward , Jouke-Jan Hottenga , Kevin B Jacobs , Joshua W Knowles , Zoltán Kutalik , Keri L Monda , Ozren Polasek , Michael Preuss , Nigel W Rayner , Neil R Robertson , Valgerdur Steinthorsdottir , Jonathan P Tyrer , Benjamin F Voight , Fredrik Wiklund , Jianfeng Xu , Jing Hua Zhao , Dale R Nyholt , Niina Pellikka , Markus Perola , John R B Perry , Ida Surakka , Mari-Liis Tammesoo , Elizabeth L Altmaier , Najaf Amin , Thor Aspelund , Tushar Bhangale , Gabrielle Boucher , Daniel I Chasman , Constance Chen , Lachlan Coin , Matthew N Cooper , Anna L Dixon , Quince Gibson , Elin Grundberg , Ke Hao , M Juhani Junttila , Lee M Kaplan , Johannes Kettunen , Inke R König , Tony Kwan , Robert W Lawrence , Douglas F Levinson , Mattias Lorentzon , Barbara McKnight , Andrew P Morris , Martina Müller , Julius Suh Ngwa , Shaun Purcell , Suzanne Rafelt , Rany M Salem , Erika Salvi , Serena Sanna , Jianxin Shi , Ulla Sovio , John R Thompson , Michael C Turchin , Liesbeth Vandenput , Dominique J Verlaan , Veronique Vitart , Charles C White , Andreas Ziegler , Peter Almgren , Anthony J Balmforth , Harry Campbell , Lorena Citterio , Alessandro De Grandi , Anna Dominiczak , Jubao Duan , Paul Elliott , Roberto Elosua , Johan G Eriksson , Nelson B Freimer , Eco J C Geus , Nicola Glorioso , Shen Haiqing , Anna-Liisa Hartikainen , Aki S Havulinna , Andrew A Hicks , Jennie Hui , Wilmar Igl , Thomas Illig , Antti Jula , Eero Kajantie , Tuomas O Kilpeläinen , Markku Koiranen , Ivana Kolcic , Seppo Koskinen , Peter Kovacs , Jaana Laitinen , Jianjun Liu , Marja-Liisa Lokki , Ana Marusic , Andrea Maschio , Thomas Meitinger , Antonella Mulas , Guillaume Paré , Alex N Parker , John F Peden , Astrid Petersmann , Irene Pichler , Kirsi H Pietiläinen , Anneli Pouta , Martin Ridderstråle , Jerome I Rotter , Jennifer G Sambrook , Alan R Sanders , Carsten Oliver Schmidt , Juha Sinisalo , Jan H Smit , Heather M Stringham , G Bragi Walters , Elisabeth Widen , Sarah H Wild , Gonneke Willemsen , Laura Zagato , Lina Zgaga , Paavo Zitting , Helene Alavere , Martin Farrall , Wendy L McArdle , Mari Nelis , Marjolein J Peters , Samuli Ripatti , Joyce B J van Meurs , Katja K Aben , Kristin G Ardlie , Jacques S Beckmann , John P Beilby , Richard N Bergman , Sven Bergmann , Francis S Collins , Daniele Cusi , Martin den Heijer , Gudny Eiriksdottir , Pablo V Gejman , Alistair S Hall , Anders Hamsten , Heikki V Huikuri , Carlos Iribarren , Mika Kähönen , Jaakko Kaprio , Sekar Kathiresan , Lambertus Kiemeney , Thomas Kocher , Lenore J Launer , Terho Lehtimäki , Olle Melander , Tom H Mosley , Arthur W Musk , Markku S Nieminen , Christopher J O'Donnell , Claes Ohlsson , Ben Oostra , Lyle J Palmer , Olli Raitakari , Paul M Ridker , John D Rioux , Aila Rissanen , Carlo Rivolta , Heribert Schunkert , Alan R Shuldiner , David S Siscovick , Michael Stumvoll , Anke Tönjes , Jaakko Tuomilehto , Gert-Jan van Ommen , Jorma Viikari , Andrew C Heath , Nicholas G Martin , Grant W Montgomery , Michael A Province , Manfred Kayser , Alice M Arnold , Larry D Atwood , Eric Boerwinkle , Stephen J Chanock , Panos Deloukas , Christian Gieger , Henrik Grönberg , Per Hall , Andrew T Hattersley , Christian Hengstenberg , Wolfgang Hoffman , G Mark Lathrop , Veikko Salomaa , Stefan Schreiber , Manuela Uda , Dawn Waterworth , Alan F Wright , Themistocles L Assimes , Inês Barroso , Albert Hofman , Karen L Mohlke , Dorret I Boomsma , Mark J Caulfield , L Adrienne Cupples , Jeanette Erdmann , Caroline S Fox , Vilmundur Gudnason , Ulf Gyllensten , Tamara B Harris , Richard B Hayes , Marjo-Riitta Jarvelin , Vincent Mooser , Patricia B Munroe , Willem H Ouwehand , Brenda W Penninx , Peter P Pramstaller , Thomas Quertermous , Igor Rudan , Nilesh J Samani , Timothy D Spector , Henry Völzke , Hugh Watkins , James F Wilson , Leif C Groop , Talin Haritunians , Frank B Hu , Robert C Kaplan , Andres Metspalu , Kari E North , David Schlessinger , Nicholas J Wareham , David J Hunter , Jeffrey R O'Connell , David P Strachan , H-Erich Wichmann , Ingrid B Borecki , Cornelia M van Duijn , Eric E Schadt , Unnur Thorsteinsdottir , Leena Peltonen , André G Uitterlinden , Peter M Visscher , Nilanjan Chatterjee , Ruth J F Loos , Michael Boehnke , Mark I McCarthy , Erik Ingelsson , Cecilia M Lindgren , Gonçalo R Abecasis , Kari Stefansson , Timothy M Frayling , Joel N Hirschhorn |
2010-10-14 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员