| Type | Description |
|---|---|
| Definition | checkpoint kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:19:00 | CHK2 is essential for spindle assembly and DNA repair during the first cleavage of mouse embryos. | 32484784 |
| 2019-09-14 10:39:00 | this study defines a role for Chk2 in suppressing UV-induced skin carcinogenesis | 29859927 |
| 2019-07-20 11:00:00 | Chk2 deletion in Pthrp KI mice can somewhat rescue defects in osteoblastic bone formation and skeletal growth by enhancing endochondral bone formation and osteogenesis | 29805302 |
| 2017-09-23 12:55:00 | work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF/NF-kappaB-regulated apoptosis and the p53/PCNA- and ATM/ATR-Chk1/2-controlled DNA-damage response pathways. | 26887372 |
| 2017-08-19 10:54:00 | Together, this study described the regulation of Chk2 expression through promoter methylation by Dnmt3b and also presented a novel role of Chk2 during neuronal differentiation, which is independent of its previously known function in DNA damage response. | 28712951 |
| Type | IDs |
|---|---|
| Synonymous | CHK2, Cds1, HUCDS1, Rad53 |
| Gene |
UniProtKB-ID:
CHK2_MOUSE,
Q543W6_MOUSE
UniprotKB:
Q9Z265,
Q543W6
UniParc:
UPI0000004062
EMBL:
AF086905,
AK044913,
BC056617
Ensembl:
ENSMUSG00000029521
KO:
mmu:50883
|
| Nucleutide sequences |
EMBL-CDS:
AAH56617.1,
AAC83694.1,
BAC32138.1
Ensembl_TRS:
ENSMUST00000066160
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000066679
RefSeq:
XP_030110519.1,
XP_030110520.1,
NP_057890.1,
XP_006535134.3,
XP_006535132.1,
XP_006535131.3,
NP_001350237.1,
XP_006535133.1,
XP_036021156.1
|
| Others |
UniRef100:
UniRef100_Q9Z265
UniRef90:
UniRef90_Q9Z265
UniRef50:
UniRef50_O96017
UniGene:
Mm.279308
CCDS:
CCDS19533.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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