| Type | Description |
|---|---|
| Definition | selenocysteine lyase |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 13:13:00 | Studied the role of selenocysteine lyase in amino acid metabolism using knockout mice and a combination of transcriptomics and metabolomics. | 31717805 |
| 2020-02-01 11:28:00 | Loss of Scly within a neuronal sub-population that makes up a small fraction of the hypothalamus produces a phenotype in mice distinguished by reduced weight gain while on high fat diet and resistance to the development of leptin insensitivity. | 31340540 |
| 2018-09-01 11:00:00 | Selenocysteine lyase regulates energy metabolism via the hypothalamus. | 29385050 |
| 2016-03-05 11:11:00 | This study showed that Male mice lacking two key genes involved in Se metabolism (Scly(-/-)Sepp1(-/-) mice), selenoprotein P (Sepp1) and Sec lyase (Scly), develop severe neurological dysfunction, neurodegeneration, and audiogenic seizures. | 26586820 |
| 2015-08-15 11:24:00 | our findings unveil a new metabolic role for Reg3beta in protein nitration and a new biosynthesis control of GPX1 by a completely "unrelated" regenerating protein, Reg3beta, via transcriptional activation of Scly | 23811004 |
| Type | IDs |
|---|---|
| Synonymous | 9830169H08, A930015N15Rik, SCL, Scly1, Scly2 |
| Gene |
UniProtKB-ID:
SCLY_MOUSE,
A0A0R4J069_MOUSE
UniprotKB:
Q9JLI6,
A0A0R4J069
UniParc:
UPI0000028DA0,
UPI0000022876,
UPI000163AC7E
EMBL:
BC019879,
AC102874,
BC021389,
AK036533,
AF175407,
AC110510,
AK036750
Ensembl:
ENSMUSG00000026307
KO:
mmu:50880
|
| Nucleutide sequences |
EMBL-CDS:
BAC29563.1,
AAH19879.1,
BAC29465.1,
AAF36812.1,
AAH21389.1
Ensembl_TRS:
ENSMUST00000027532
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000027532
RefSeq:
XP_006529809.1,
XP_006529807.1,
XP_036008194.1,
XP_006529806.2,
XP_006529808.1,
NP_057926.2
|
| Others |
UniRef100:
UniRef100_A0A0R4J069,
UniRef100_Q9JLI6
UniRef90:
UniRef90_Q9JLI6
UniRef50:
UniRef50_Q9JLI6
UniGene:
Mm.25724
CCDS:
CCDS15159.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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