| Type | Description |
|---|---|
| Definition | spastin |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:59:00 | Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits. | 32866173 |
| 2020-02-08 11:35:00 | Collectively, these data demonstrate that spastin controls brain development by the regulation of neural stem cell functions at early developmental stages. | 31150727 |
| 2019-03-23 11:18:00 | two isoforms of spastin harboring the same missense mutation bind and bundle different subsets of microtubules. | 30213879 |
| 2018-12-01 11:28:00 | Spastin regulates VAMP7-containing vesicles trafficking in cortical neurons. | 28392418 |
| 2017-07-29 12:52:00 | Axon branch loss at the developing mouse neuromuscular junction is mediated by branch-specific microtubule severing, mediated by the microtubule-severing enzyme spastin. | 27773584 |
| Type | IDs |
|---|---|
| Synonymous | Spg4, mKIAA1083 |
| Gene |
UniProtKB-ID:
SPAST_MOUSE,
A0A286YE25_MOUSE
UniprotKB:
Q9QYY8,
A0A286YE25
UniParc:
UPI0007A6A52D,
UPI0001AADE55,
UPI0000D8B4C8
EMBL:
AK129282,
BC046286,
AK007793,
AC169506,
AJ246002
Ensembl:
ENSMUSG00000024068
KO:
mmu:50850
|
| Nucleutide sequences |
EMBL-CDS:
AAH46286.1,
BAB25259.1,
BAC98092.1,
CAB60143.1
Ensembl_TRS:
ENSMUST00000024869,
ENSMUST00000224711
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000024869,
ENSMUSP00000153469
RefSeq:
XP_006524673.1,
NP_058658.2,
NP_001156342.1,
XP_036016574.1,
NP_001344667.1
|
| Others |
UniRef100:
UniRef100_A0A286YE25,
UniRef100_Q9QYY8
UniRef90:
UniRef90_Q9QYY8
UniRef50:
UniRef50_Q9UBP0
UniGene:
Mm.19804
CCDS:
CCDS50181.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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