| Type | Description |
|---|---|
| Definition | poly(A)-specific ribonuclease |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:59:00 | Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN). | 31936572 |
| 2021-01-16 15:54:00 | Regulation of poly(a)-specific ribonuclease activity by reversible lysine acetylation. | 32457045 |
| 2020-09-19 15:14:00 | PARN regulates miRNA levels by stabilizing either mature or precursor miRNAs by removing oligo(A) tails added by the poly(A) polymerase PAPD5, which if remaining recruit the exonuclease DIS3L or DIS3L2 to degrade the miRNA. PARN knockdown destabilizes multiple miRNAs that repress p53 translation, leading to p53 accumulation. | 30770239 |
| 2020-05-09 11:18:00 | Study reports a family with idiopathic pulmonary fibrosis with a rare missense mutation, p.Y91C, and a novel insertion, p.(I274*) in PARN gene. PARN p.Y91C had reduced deadenylase activity and the p.(I274*) transcript was depleted. | 31448843 |
| 2020-04-25 12:37:00 | Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models. | 31273937 |
| Type | IDs |
|---|---|
| Synonymous | DAN, DKCB6, PFBMFT4 |
| Gene |
UniProtKB-ID:
PARN_HUMAN,
A0A494C0Q2_HUMAN,
B3KN69_HUMAN,
A0A494C1K5_HUMAN
UniprotKB:
O95453,
A0A494C0Q2,
B3KN69,
A0A494C1K5
UniParc:
UPI00017A7A0C,
UPI0005D02E14,
UPI00017A8152,
UPI0005CFF12F,
UPI0000031F7A,
UPI000015F6B1,
UPI00017A6CDE
EMBL:
KF456163,
AK023866,
AK315020,
CH471112,
AC092291,
AK301648,
AK293189,
AK299653,
AC009167,
BC050029,
AJ005698
Ensembl:
ENSG00000140694,
ENSG00000274829
KO:
hsa:5073
|
| Nucleutide sequences |
EMBL-CDS:
EAW85110.1,
BAG56729.1,
CAA06683.1,
BAG61572.1,
BAG63126.1,
AAH50029.1,
BAG37510.1,
BAG51231.1
Ensembl_TRS:
ENST00000618929,
ENST00000437198,
ENST00000539279,
ENST00000420015,
ENST00000615183,
ENST00000634004,
ENST00000631868,
ENST00000341484,
ENST00000651049,
ENST00000651634
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000387911,
ENSP00000487634,
ENSP00000410525,
ENSP00000444381,
ENSP00000478668,
ENSP00000345456,
ENSP00000488554,
ENSP00000484279,
ENSP00000498644,
ENSP00000499078
RefSeq:
XP_016878748.1,
XP_016878749.1,
XP_011520813.1,
XP_011520815.1,
XP_024306060.1,
XP_016878747.1,
NP_001127949.1,
XP_011520816.1,
NP_002573.1,
NP_001229921.1,
XP_011520812.1
|
| Others |
UniRef100:
UniRef100_O95453,
UniRef100_A0A494C0Q2,
UniRef100_A0A494C1K5
UniRef90:
UniRef90_O95453
UniRef50:
UniRef50_O95453
UniGene:
Hs.253197
CCDS:
CCDS58425.1,
CCDS45420.1,
CCDS45419.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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