| Type | Description |
|---|---|
| Definition | Rho guanine nucleotide exchange factor 4 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:13:00 | Conformational Selection Mechanism Provides Structural Insights into the Optimization of APC-Asef Inhibitors. | 33670371 |
| 2019-06-29 10:13:00 | The armadillo repeats in full-length APC interact with the APC residues 1362 to 1540 (APC-2,3 repeats), and this interaction competes off and inhibits Asef. Deletion of APC-2,3 repeats permits Asef interactions leading to downstream signaling events, including the induction of Golgi fragmentation through the activation of the Asef-ROCK-MLC2. | 29866653 |
| 2019-02-02 11:45:00 | Evaluation of an immunohistochemical staining of 102 resected pancreatic cancer samples demonstrated that high ARHGEF4 expression was correlated with an independent predictor of worse overall survival. ARHGEF4 induces the formation of cell protrusions by increasing phosphorylated ERK1/2 and GSK-3alpha/beta, resulting in an increase in motility and invasiveness in pancreatic ductal adenocarcinoma cells. | 30226582 |
| 2018-03-03 10:54:00 | Our results indicate a possible contribution of CNVs in LEPR, NEGR1, ARHGEF4, and CPXCR1 and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d to the development of obesity, particularly abdominal obesity in Mexican children. | 28428959 |
| 2017-05-27 10:54:00 | Although inappropriate promoter methylation was not invariantly associated with reduced transcript expression, a significant association was apparent for the ARHGEF4, PON3, and VAX2 gene transcripts (P<0.05). Herein, we present the first genome-wide DNA methylation analysis in a unique HG-NMIBC cohort, showing extensive and discrete methylation changes relative to normal bladder and low-intermediate-grade tumor | 26929985 |
| Type | IDs |
|---|---|
| Synonymous | ASEF, ASEF1, GEF4, SMIM39, STM6 |
| Gene |
UniProtKB-ID:
ARHG4_HUMAN,
Q9NTG0_HUMAN
UniprotKB:
Q9NR80,
Q9NTG0
UniParc:
UPI00001417F6,
UPI00000728D7,
UPI0000161C0C,
UPI00000738F3
EMBL:
AF249745,
AL137289,
AB029035,
AB042199
Ensembl:
ENSG00000136002
KO:
hsa:50649
|
| Nucleutide sequences |
EMBL-CDS:
BAB11941.1,
BAA83064.1,
AAF79955.1,
CAB70681.1
Ensembl_TRS:
ENST00000355771,
ENST00000326016
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000316845,
ENSP00000348017
RefSeq:
NP_001354422.1,
NP_001362833.1,
NP_001362831.1,
NP_056135.2,
XP_016859720.1,
XP_011509578.1,
XP_011509579.1,
NP_001362829.1,
NP_001362830.1,
XP_005263746.1,
XP_005263745.1,
XP_011509576.1,
XP_024308706.1,
NP_001362832.1
|
| Others |
UniRef100:
UniRef100_Q9NR80
UniRef90:
UniRef90_Q9NR80
UniRef50:
UniRef50_Q9NR80
UniGene:
Hs.469935
CCDS:
CCDS2165.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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