| Type | Description |
|---|---|
| Definition | patatin like phospholipase domain containing 8 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:39:00 | 12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA2gamma knockout. | 32161117 |
| 2019-05-25 11:38:00 | we report two unrelated individuals with variable but similar clinical features of microcephaly, severe global developmental delay, spasticity, lactic acidosis, and progressive cerebellar atrophy with biallelic loss-of-function variants in PNPLA8. | 29681094 |
| 2018-12-01 11:38:00 | Stable isotope kinetics revealed that in non-failing human hearts, cPLA2zeta metabolically channels arachidonic acid into EETs, whereas in failing hearts, increased iPLA2gamma activity channels AA into toxic HETEs. These results mechanistically identify the sequelae of pathological remodeling of human mitochondrial phospholipases in failing myocardium. | 29158256 |
| 2015-06-20 12:30:00 | iPLA2gamma plays an important role in in vivo Thromboxane A2 production accompanied by thrombus formation. | 25313821 |
| 2013-08-31 12:09:00 | iPLA2gamma plays a cardioprotective role during the acute stage of Chagas' disease. | 23429536 |
| Type | IDs |
|---|---|
| Synonymous | IPLA2-2, IPLA2G, MMLA, PNPLA-gamma, iPLA2gamma |
| Gene |
UniProtKB-ID:
PLPL8_HUMAN,
A0A024R746_HUMAN
UniprotKB:
Q9NP80,
A0A024R746
UniParc:
UPI0000073D34,
UPI0000EE406A,
UPI000006EBDA
EMBL:
CH471070,
AL834147,
AF263613,
CH236947,
AB041261,
BX647865,
AC005058,
AK024335,
AK002115,
BC032999,
AF263947,
AF217519
Ensembl:
ENSG00000135241
KO:
hsa:50640
|
| Nucleutide sequences |
EMBL-CDS:
AAF75269.1,
AAF81246.1,
EAL24384.1,
BAA92090.1,
AAD08847.1,
BAB14890.1,
CAD38859.1,
AAH32999.1,
EAL24385.1,
EAW83433.1,
AAF67630.1,
BAA94997.1,
EAW83432.1,
EAW83434.1,
EAW83435.1
Gene_ORFName:
BM-043,
hCG_17116
Ensembl_TRS:
ENST00000426128,
ENST00000436062,
ENST00000257694,
ENST00000453144,
ENST00000422087
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000387789,
ENSP00000257694,
ENSP00000406779,
ENSP00000410804,
ENSP00000394988
RefSeq:
NP_001242938.1,
XP_011514576.1,
XP_005250453.1,
NP_001242936.1,
NP_001242939.1,
NP_001242937.1,
NP_001242940.1,
XP_011514577.1,
NP_056538.1,
XP_016867750.1
|
| Others |
UniRef100:
UniRef100_Q9NP80
UniRef90:
UniRef90_Q9NP80
UniRef50:
UniRef50_Q9NP80
UniGene:
Hs.617340
CCDS:
CCDS34733.1,
CCDS59075.1,
CCDS59508.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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