| Type | Description |
|---|---|
| Definition | large tumor suppressor 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:32:00 | MicroRNA93 promotes angiogenesis and attenuates remodeling via inactivation of the Hippo/Yap pathway by targeting Lats2 after myocardial infarctionomega. | 32319642 |
| 2021-01-09 13:27:00 | Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate. | 32243503 |
| 2020-06-27 11:45:00 | Data show that conditional deletion of the key Hippo kinases Lats1 and Lats2 in mouse Mullerian duct mesenchyme cells caused them to adopt the myofibroblast cell fate, resulting in profound reproductive tract developmental defects and sterility. | 31575647 |
| 2020-06-06 11:48:00 | Inactivation of Lats1/2 in granulosa cells either in vitro or in vivo resulted in a loss of granulosa cell morphology, function, and gene expression. Mutant cells further underwent changes in structure and gene expression suggestive of epithelial-to-mesenchymal transition and transdifferentiation into multiple lineages. | 31268774 |
| 2020-04-18 12:36:00 | Lats1 and Lats2 suppress mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. | 32015438 |
| Type | IDs |
|---|---|
| Synonymous | 4932411G09Rik, AV277261, AW228608 |
| Gene |
UniProtKB-ID:
LATS2_MOUSE,
Q8VHE2_MOUSE
UniprotKB:
Q7TSJ6,
Q8VHE2
UniParc:
UPI00000246CF,
UPI0000021D83
EMBL:
AK029966,
AC154504,
AY015061,
BC053028,
AB023958
Ensembl:
ENSMUSG00000021959
KO:
mmu:50523
|
| Nucleutide sequences |
EMBL-CDS:
BAA92380.1,
BAC26704.1,
AAH53028.1,
AAK07725.1
Ensembl_TRS:
ENSMUST00000022531,
ENSMUST00000077981
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000022531,
ENSMUSP00000077130
RefSeq:
NP_700431.1,
XP_006519287.1,
NP_056586.2,
XP_006519288.1
|
| Others |
UniRef100:
UniRef100_Q7TSJ6,
UniRef100_Q8VHE2
UniRef90:
UniRef90_Q7TSJ6,
UniRef90_Q8VHE2
UniRef50:
UniRef50_Q7TSJ6,
UniRef50_Q8VHE2
UniGene:
Mm.347899
CCDS:
CCDS27158.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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