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50515 CHST11

50515

CHST11

carbohydrate sulfotransferase 11

protein-coding

Homo sapiens

基因描述

Type Description
Definition carbohydrate sulfotransferase 11

研究结论

Date Results Publications
2021-02-06 13:50:00 Carbohydrate (Chondroitin 4) Sulfotransferase-11-Mediated Induction of Epithelial-Mesenchymal Transition and Generation of Cancer Stem Cells. 32344408
2019-10-05 10:39:00 Our findings confirm the crucial role of CHST11 in skeletal morphogenesis and show that CHST11 defects have variable manifestations that include a variety of limb malformations and skeletal defects 29514872
2018-02-10 11:38:00 A C4ST-1 construct was designed and expressed in both Escherichia coli and Pichia pastoris in its non-glycosylated and glycosylated forms. Both constructs showed similar activity albeit different kinetic parameters when acting on a microbially prepared unsulfated chondroitin substrate. Moreover, the glycosylated form of C4ST-1 showed lower stability than the non-glycosylated form. 28761999
2017-07-22 11:24:00 data demonstrate that the hip osteoarthritis susceptibility is mediated by differential protein binding to the alleles of rs835487 and rs835488, which are located within an enhancer whose target may be CHST11 during chondrogenesis or an alternative gene. 27391021
2017-07-15 12:12:00 These results have demonstrated that CHST11 and CHST13 negatively modulate metastasis and drug resistance of HCC cells probably via oncogenic MAPK signal pathway. 26993826

名称对应

Type IDs
Synonymous C4ST, C4ST-1, C4ST1, HSA269537, OCBMD
Gene
UniProtKB-ID: CHSTB_HUMAN, A0A024RBL0_HUMAN
UniprotKB: Q9NPF2, A0A024RBL0
UniParc: UPI00000467CB, UPI000004A091
EMBL: AB042326, BC013315, AJ289134, AJ269537, AF239820, CH471054, AK290923
Ensembl: ENSG00000171310
KO: hsa:50515
Nucleutide sequences
EMBL-CDS: CAB92134.1, BAF83612.1, CAB87380.1, AAH13315.1, BAA95485.1, AAF81691.1, EAW97748.1, EAW97749.1
Gene_ORFName: hCG_2015274
Ensembl_TRS: ENST00000303694, ENST00000549260
Protein sequencees
Ensembl_PRO: ENSP00000450004, ENSP00000305725
RefSeq: NP_001167453.1, NP_060883.1, XP_016874858.1
Others
UniRef100: UniRef100_Q9NPF2
UniRef90: UniRef90_Q9JME2
UniRef50: UniRef50_Q9JME2
UniGene: Hs.17569
CCDS: CCDS55878.1, CCDS9099.1

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