| Type | Description |
|---|---|
| Definition | prolyl 4-hydroxylase subunit alpha 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:57:00 | Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls. | 32053263 |
| 2020-12-19 13:37:00 | High P4HA1 expression is an independent prognostic factor for poor overall survival and recurrent-free survival in head and neck squamous cell carcinoma. | 31782831 |
| 2020-07-11 10:39:00 | Findings show that prolyl 4-hydroxylase subunit alpha 1 (P4HA1) can enhance hypoxia-inducible factor 1alpha (HIF1alpha) stability, indicating a positive feedback loop between HIF1alpha and P4HA1 in pancreatic ductal adenocarcinoma (PDAC). | 31239153 |
| 2020-05-23 10:56:00 | Diagnostic and Prognostic Values of P4HA1 Expression in Lung Cancer, Breast Cancer, and Head and Neck Cancer | 32150689 |
| 2019-01-12 11:58:00 | Collagen prolyl 4-hydroxylase alpha 1 subunit (P4HA1) protein expression is induced in triple-negative breast cancer (TNBC) and HER2 positive breast cancer. Inhibition of P4HA1 sensitizes TNBC to the chemotherapeutic agent docetaxel and doxorubicin in xenografts and patient-derived models. Increased P4HA1 expression correlates with short relapse-free survival in TNBC patients who received chemotherapy. | 30367042 |
| Type | IDs |
|---|---|
| Synonymous | P4HA |
| Gene |
UniProtKB-ID:
P4HA1_HUMAN,
Q5VSQ6_HUMAN
UniprotKB:
P13674,
Q5VSQ6
UniParc:
UPI000002B050,
UPI0000001C27,
UPI0000E224ED
EMBL:
U14616,
U14608,
U14612,
U14605,
CD013929,
U14615,
U14613,
U14607,
U14617,
AL731563,
U14610,
BC034998,
CH471083,
U14614,
U14618,
M24487,
U14619,
U14620,
U14609,
M24486,
AK222960,
U14611
Ensembl:
ENSG00000122884
KO:
hsa:5033
|
| Nucleutide sequences |
EMBL-CDS:
AAA36535.1,
AAA59069.1,
AAA36534.1,
AAH34998.1,
AAA59068.1,
EAW54468.1,
BAD96680.1,
EAW54467.1
Gene_ORFName:
hCG_19276
Ensembl_TRS:
ENST00000373008,
ENST00000307116,
ENST00000394890,
ENST00000440381,
ENST00000263556
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000263556,
ENSP00000414464,
ENSP00000362099,
ENSP00000378353,
ENSP00000307318
RefSeq:
NP_001017962.1,
NP_001136068.1,
NP_001136067.1,
NP_000908.2
|
| Others |
UniRef100:
UniRef100_A0A6D2X6U4,
UniRef100_P13674
UniRef90:
UniRef90_P13674
UniRef50:
UniRef50_P13674
UniGene:
Hs.500047,
Hs.593005
CCDS:
CCDS44432.1,
CCDS41537.1,
CCDS7320.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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