| Type | Description |
|---|---|
| Definition | orthodenticle homeobox 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:30:00 | Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells. | 31845906 |
| 2020-03-28 11:53:00 | Authors found that the function of DMBX1 was dependent on p21 (CDKN1A), a key regulator of G1/S cell cycle progression. Co-IP assay revealed that DMBX1 directly bound to another homeobox transcription factor, OTX2. ChIP and luciferase reporter assay confirmed that OTX2 directly interacted with the promoter region of p21 to enhance its transcription, and DMBX1 repressed OTX2-mediated transcription of p21. | 30928384 |
| 2020-01-18 12:49:00 | The OTX2 gene was expressed in 62% of 60 Brazilian medulloblastoma patients. Expression varied with age (higher in younger age groups), location (predominantly vermis), and histological type (classic and anaplastic). A statistical correlation between OTX2 gene expression and the development of leptomeningeal metastases was observed. | 30797919 |
| 2019-07-27 12:15:00 | study provides mechanistic insight into the networks controlled by OTX2 in Medulloblastoma (MB) stem/progenitor cells and reveals novel roles for axon guidance genes and their downstream effectors as putative tumor suppressors in MB. | 29377567 |
| 2019-03-16 13:09:00 | Maltreatment history and DNA methylation in OTX2 significantly predicted depression in children. | 30089883 |
| Type | IDs |
|---|---|
| Synonymous | CPHD6, MCOPS5 |
| Gene |
UniProtKB-ID:
OTX2_HUMAN,
F1T0D1_HUMAN,
F1T0C9_HUMAN,
F1T0D0_HUMAN
UniprotKB:
P32243,
F1T0D1,
F1T0C9,
F1T0D0
UniParc:
UPI0000130F39,
UPI0002003FCD,
UPI0002003FCE,
UPI000000161B
EMBL:
BC032579,
AK314271,
AB593058,
AB593056,
AL161757,
CH471061,
AF093138,
AB037505,
AB593057,
AF298117
Ensembl:
ENSG00000165588
KO:
hsa:5015
|
| Nucleutide sequences |
EMBL-CDS:
EAW80692.1,
AAG16243.1,
BAG36932.1,
BAA90425.1,
AAH32579.1,
AAD31385.1,
EAW80693.1,
BAJ84005.1,
BAJ84003.1,
BAJ84004.1
Gene_ORFName:
hCG_32530
Ensembl_TRS:
ENST00000673481,
ENST00000555006,
ENST00000408990,
ENST00000339475,
ENST00000673035,
ENST00000672264,
ENST00000554788,
ENST00000554559
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000343819,
ENSP00000500595,
ENSP00000452336,
ENSP00000386185,
ENSP00000500061,
ENSP00000500115,
ENSP00000450468,
ENSP00000474486
RefSeq:
NP_758840.1,
NP_001257454.1,
NP_068374.1,
NP_001257452.1,
NP_001257453.1
|
| Others |
UniRef100:
UniRef100_P32243,
UniRef100_F1T0C9,
UniRef100_F1T0D1
UniRef90:
UniRef90_P32243,
UniRef90_F1T0C9
UniRef50:
UniRef50_F1T0C9,
UniRef50_P32243
UniGene:
Hs.288655,
Hs.741558
CCDS:
CCDS9728.1,
CCDS41960.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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