| Type | Description |
|---|---|
| Definition | origin recognition complex subunit 4 |
| Date | Results | Publications |
|---|---|---|
| 2017-11-11 12:32:00 | Since the site of one of the missense mutations in the human ORC4 alleles is conserved between humans and yeast, we sought to determine in what way this single amino acid change affects the process of chromosome replication, by introducing the comparable mutation into yeast (orc4Y232C). | 29036220 |
| 2016-08-13 10:23:00 | HsOrc4 could have a fundamental function in the process of initiation of replication by remodeling the structure of origin of replication using the energy of supercoiled DNA. | 26124052 |
| 2012-09-22 11:20:00 | compared with homozygous missense mutations, compound heterozygous mutations appeared to have a more severe effect on phenotype, causing more severe growth retardation in ORC4 | 22333897 |
| 2011-05-14 10:46:00 | identified three different mutations in the gene encoding ORC4, a component of the eukaryotic origin recognition complex, in five individuals with Meier-Gorlin syndrome | 21358631 |
| 2010-10-04 12:41:00 | DNA binding activity of HsOrc4 depends on length and structure of DNA with triplex being the protein's preferred binding target. | 19690980 |
| Type | IDs |
|---|---|
| Synonymous | ORC4L, ORC4P |
| Gene |
UniProtKB-ID:
ORC4_HUMAN,
Q96B14_HUMAN,
A8K7H4_HUMAN
UniprotKB:
O43929,
Q96B14,
A8K7H4
UniParc:
UPI0001DB95B4,
UPI00015DA7CF,
UPI0000073A5F,
UPI000013D4D3,
UPI0000208C3D
EMBL:
AF047598,
AK295721,
AK291989,
AY600302,
BC014847,
AF022108,
CH471058,
AK298862,
BC016177,
AF132596,
AC019226,
AC009480
Ensembl:
ENSG00000115947
KO:
hsa:5000
|
| Nucleutide sequences |
EMBL-CDS:
EAX11557.1,
EAX11555.1,
BAH12166.1,
AAC01957.1,
EAX11556.1,
BAH12887.1,
AAC80282.1,
AAD22110.1,
AAH14847.1,
EAX11558.1,
AAS94326.1,
AAH16177.1,
BAF84678.1
Ensembl_TRS:
ENST00000392857,
ENST00000536575,
ENST00000264169,
ENST00000535373,
ENST00000540442
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000376597,
ENSP00000264169,
ENSP00000441502,
ENSP00000441953,
ENSP00000438326
RefSeq:
NP_001177811.1,
NP_001177808.1,
NP_001177810.1,
NP_001361201.1,
NP_859525.1,
XP_011509557.1,
NP_001361199.1,
NP_859526.1,
NP_002543.2
|
| Others |
UniRef100:
UniRef100_O43929,
UniRef100_A8K7H4
UniRef90:
UniRef90_O43929
UniRef50:
UniRef50_O43929
UniGene:
Hs.558364
CCDS:
CCDS2187.1,
CCDS54405.1,
CCDS54404.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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