| Type | Description |
|---|---|
| Definition | origin recognition complex subunit 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:48:00 | Origin recognition complex subunit 1 regulates cell growth and metastasis in glioma by altering activation of ERK and JNK signaling pathway. | 31866342 |
| 2020-05-09 11:53:00 | Authors report the crystal structure of Cyclin A-CDK2 complex bound to a peptide derived from ORC1 at 2.54 a resolution; structure revealed that the ORC1 peptide interacts with a hydrophobic groove, termed cyclin binding groove, of Cyclin A via a KXL motif. | 31309634 |
| 2017-11-18 10:29:00 | The opposing effects of ORC1 (represor) and CDC6 (gene activator) in controlling the level of Cyclin E ensures genome stability and a mechanism for linking directly DNA replication and cell division commitment. | 27458800 |
| 2017-11-04 12:11:00 | The authors have discovered that human cell lines in culture proliferate with intact chromosomal origins of replication after disruption of both alleles of ORC2 or of the ATPase subunit, ORC1. | 27906128 |
| 2015-08-08 10:39:00 | Orc1 acts as a nucleating center for origin recognition complex assembly and then pre-replication complex assembly by binding to mitotic chromosomes, followed by gradual removal from chromatin during the G1 phase. | 25784553 |
| Type | IDs |
|---|---|
| Synonymous | HSORC1, ORC1L, PARC1 |
| Gene |
UniProtKB-ID:
ORC1_HUMAN,
B7Z8H0_HUMAN,
Q96F82_HUMAN
UniprotKB:
Q13415,
B7Z8H0,
Q96F82
UniParc:
UPI000013D2FB,
UPI000006F33A,
UPI0001915074
EMBL:
CH471059,
U43416,
U40152,
AK303420,
AL513218,
BC011539
Ensembl:
ENSG00000085840
KO:
hsa:4998
|
| Nucleutide sequences |
EMBL-CDS:
EAX06783.1,
EAX06784.1,
AAA86260.1,
AAC50325.1,
BAH13956.1,
AAH11539.1
Ensembl_TRS:
ENST00000371566,
ENST00000371568
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000360621,
ENSP00000360623
RefSeq:
XP_016856878.1,
NP_001177747.1,
XP_011539829.1,
XP_016856877.1,
NP_004144.2,
NP_001177748.1
|
| Others |
UniRef100:
UniRef100_B7Z8H0,
UniRef100_Q13415,
UniRef100_Q96F82
UniRef90:
UniRef90_Q13415
UniRef50:
UniRef50_Q13415
UniGene:
Hs.17908
CCDS:
CCDS566.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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