| Type | Description |
|---|---|
| Definition | opioid receptor kappa 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:55:00 | The Kappa Opioid Receptor Is Associated With Naltrexone-Induced Reduction of Drinking and Craving. | 31399255 |
| 2020-06-27 10:58:00 | The OPRK1 rs3802279, rs3802281, and rs963549 genotypes were significantly associated with methadone dosage analyzed by Pearson's chi-square test or binary logistic regression to correct for covariates. The rs3802279 CC, rs3802281 TT, and rs963549 CC genotype carriers required a lower methadone maintenance dose per day. Multifactor analysis indicated strong interactions between sex and OPRK1 rs963549. | 31940240 |
| 2020-06-13 10:44:00 | Reactive oxygen species generation is stimulated by kappa opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation | 31575661 |
| 2020-03-21 11:44:00 | There was an inverse correlation between social status and KOR levels that was largely specific to the reward/aversion (e.g., saliency) areas of the brain. This finding suggests the KOR system may act as a mediator for the negative effects of social behaviors in humans. | 30928993 |
| 2020-03-21 11:19:00 | Greater KOR availability was associated with more choices for cocaine in subjects with cocaine use disorder. | 31026862 |
| Type | IDs |
|---|---|
| Synonymous | K-OR-1, KOR, KOR-1, OPRK |
| Gene |
UniProtKB-ID:
OPRK_HUMAN,
A0A5F9ZI09_HUMAN
UniprotKB:
P41145,
A0A5F9ZI09
UniParc:
UPI0000E0B5CD,
UPI000011D794,
UPI00073FAEA1
EMBL:
AK310233,
AF498922,
U11053,
KF458756,
U17298,
BC099912,
L37362,
AC009646,
U16860,
L36130
Ensembl:
ENSG00000082556
KO:
hsa:4986
|
| Nucleutide sequences |
EMBL-CDS:
AAA63646.1,
AAA56758.1,
AAM21070.1,
AAA63906.1,
AAC50158.1,
AAH99912.1,
AAA20985.1
Ensembl_TRS:
ENST00000613482,
ENST00000265572,
ENST00000612786,
ENST00000524278,
ENST00000520287,
ENST00000673285
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000429706,
ENSP00000430923,
ENSP00000478453,
ENSP00000265572,
ENSP00000483000,
ENSP00000500765
RefSeq:
NP_000903.2,
NP_001269833.1,
NP_001305426.1
|
| Others |
UniRef100:
UniRef100_P41145
UniRef90:
UniRef90_P41145
UniRef50:
UniRef50_P35372-3
UniGene:
Hs.106795
CCDS:
CCDS6152.1,
CCDS64895.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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