| Type | Description |
|---|---|
| Definition | oligophrenin 1 |
| Date | Results | Publications |
|---|---|---|
| 2017-09-30 11:58:00 | Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the brain ventricular dilatation observed in Ophn1(-)(/y) However, deficits in working and spatial memories are partially or not rescued by the treatment | 27146843 |
| 2017-07-29 12:44:00 | Furthermore, we found that olfactory behaviour was perturbed in OPHN1 ko mice. Chronic treatment with a Rho kinase inhibitor rescued most of the defects of the newly generated neurons. Altogether, our data indicated that OPHN1 plays a key role in regulating the number, morphology and function of adult-born inhibitory interneurons and contributed to identify potential therapeutic targets. | 27742778 |
| 2017-02-18 12:18:00 | we reported on the first male patient carrying an OPHN1 mutation with IQ score within the normal limits. This observation expands the phenotypic spectrum of OPHN1 mutations. | 27390894 |
| 2016-09-10 10:44:00 | A neuronal stem cell-based model for the treatment of OPHN1 syndrome and other neurological disorders due to ROCK dysfunction. | 27160703 |
| 2015-07-25 10:06:00 | results suggest that oligophrenin-1 is involved in tumor progression in prostate cancer | 25170626 |
| Type | IDs |
|---|---|
| Synonymous | ARHGAP41, MRX60, OPN1 |
| Gene |
UniProtKB-ID:
OPHN1_HUMAN
UniprotKB:
O60890
UniParc:
UPI000003319E,
UPI00001D6EFC
EMBL:
AJ248248,
AL672138,
AJ248262,
AJ248256,
AJ248257,
AJ248250,
AJ248253,
AJ248260,
AJ248266,
AJ248263,
AJ248246,
AJ248249,
AJ248267,
AB102656,
AJ248259,
AJ248251,
AJ248261,
AJ248254,
BC140763,
AJ248245,
BC059393,
AJ001189,
AJ248265,
AL158201,
AJ248264,
Z82203,
AJ248252,
AJ248247,
AJ248258,
AL157700,
AJ248255
Ensembl:
ENSG00000079482
KO:
hsa:4983
|
| Nucleutide sequences |
EMBL-CDS:
CAA04579.1,
AAI40764.1,
CAI42695.1,
CAI40982.1,
BAC81125.1,
CAB96181.1,
AAH59393.1,
CAD18899.2,
CAI41508.1
Ensembl_TRS:
ENST00000355520
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000347710
RefSeq:
XP_005262327.1,
XP_006724716.1,
XP_011529263.1,
XP_016885044.1,
NP_002538.1
|
| Others |
UniRef100:
UniRef100_O60890
UniRef90:
UniRef90_O60890
UniRef50:
UniRef50_O60890
UniGene:
Hs.128824
CCDS:
CCDS14388.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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