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4978 OPCML

4978

OPCML

opioid binding protein/cell adhesion molecule like

protein-coding

Homo sapiens

基因描述

Type Description
Definition opioid binding protein/cell adhesion molecule like

研究结论

Date Results Publications
2020-10-10 13:00:00 LINC00619 restricts gastric cancer progression by preventing microRNA-224-5p-mediated inhibition of OPCML. 32359894
2020-09-19 16:31:00 The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling. 31577955
2020-08-01 11:20:00 Human opioid-binding protein/cell adhesion molecule (OPCML) is expressed in many tissues and localizes to the plasma membrane. It is a putative tumor suppressor that acts on receptor tyrosine kinases, influencing cell cycle arrest, apoptosis, and migration. Its expression is silenced epigenetically in cancer, inferring potential diagnostic, prognostic, and therapeutic roles. [Review] 31421903
2019-07-20 12:04:00 OPCML promoter was found to be hypermethylated in esophageal squamous cell carcinoma (ESCC) samples. Hypermethylation of the studied OPCML promoter produced no effect on OPCML protein expression in Grade 2 tumors but revealed downregulation in Grade 3 tumors. Deranged OPCML expression may lead to high-grade ESCC as well as epigenetically regulated genes that may alter the Wnt/beta-catenin and TGF-beta-Smad pathways in ... 30880778
2019-05-18 10:04:00 OPCML and PTPRG, coordinate to repress AXL-dependent oncogenic signalling. 29907679

名称对应

Type IDs
Synonymous IGLON1, OBCAM, OPCM
Gene
UniProtKB-ID: OPCM_HUMAN, B7ZLQ0_HUMAN, A8K0Y0_HUMAN, B2CZX3_HUMAN
UniprotKB: Q14982, B7ZLQ0, A8K0Y0, B2CZX3
UniParc: UPI00001FA6FD, UPI000189A735, UPI0000055AE0, UPI0000E0019D, UPI00001A9955, UPI000172CB73
EMBL: EU562299, BC126251, EU562297, BC074773, AP004606, BC117254, AK299908, AP004782, BC143946, AP003029, AP005638, AP000903, EU562300, BC143945, AK316491, EU562298, CH471065, AP000863, AP000843, AP003784, AK316273, L34774, AP005122, EU562295, AP005133, EU562296, AK289695, AP003972, BX537377
Ensembl: ENSG00000183715
KO: hsa:4978
Nucleutide sequences
EMBL-CDS: ACB56656.1, ACB56659.1, CAD97619.1, ACB56657.1, AAI26252.1, BAH14862.1, AAA36387.1, AAH74773.1, AAI17255.1, BAG61748.1, AAI43947.1, AAI43946.1, EAW67804.1, BAF82384.1, ACB56655.1, ACB56660.1, BAH14644.1, ACB56658.1
Gene_ORFName: hCG_1811667
Ensembl_TRS: ENST00000331898, ENST00000612177, ENST00000541867, ENST00000524381, ENST00000374778
Protein sequencees
Ensembl_PRO: ENSP00000363910, ENSP00000330862, ENSP00000482061, ENSP00000434750, ENSP00000445496
RefSeq: NP_002536.1, NP_001306035.1, NP_001306032.1, XP_011541158.1, NP_001306033.1, NP_001012393.1, XP_006718909.1, NP_001306034.1
Others
UniRef100: UniRef100_Q14982, UniRef100_B7ZLQ0
UniRef90: UniRef90_B7ZLQ0, UniRef90_Q14982
UniRef50: UniRef50_Q9P121, UniRef50_P32736
UniGene: Hs.4817
CCDS: CCDS31722.1, CCDS8492.1, CCDS81649.1

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