| Type | Description |
|---|---|
| Definition | adrenocortical dysplasia |
| Date | Results | Publications |
|---|---|---|
| 2019-06-01 10:17:00 | show that TPP1 NOB is critical for telomerase function and demonstrate that the telomerase interaction surface on TPP1 is more elaborate than previously appreciated | 29386102 |
| 2018-10-27 11:24:00 | Analyses demonstrate that the majority of differentially expressed genes in acd mutant embryos are due to p53-dependent mechanisms and reflect the observed phenotypic differences between acd mutant and double mutant embryos. | 30189268 |
| 2014-05-17 10:15:00 | shelterin protein TIN2 can protect chromosome ends as a TRF2-tethered TIN2/TPP1/POT1 complex that lacks a physical connection to TRF1 | 24469404 |
| 2014-03-08 10:40:00 | Mouse hematopoietic stem cells are acutely sensitive to inactivation of the shelterin gene Acd. | 24316971 |
| 2011-10-25 18:06:00 | Mouse gene deletion experiments revealed DNA-damage-response pathways that threaten chromosome ends and how the components of the telomeric shelterin complex prevent activation of these pathways.[Shelterin] | 21209389 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
ACD_MOUSE,
B2RS36_MOUSE
UniprotKB:
Q5EE38,
B2RS36
UniParc:
UPI00004CD21F,
UPI0000D7A44D,
UPI00005AC4A8,
UPI00005B27B0,
UPI0000025634
EMBL:
BC138695,
BC004682,
AK171345,
AK032683,
AK145959,
AK030405,
BC138694,
AK160599,
AY902197
Ensembl:
ENSMUSG00000038000
KO:
mmu:497652
|
| Nucleutide sequences |
EMBL-CDS:
AAH04682.1,
BAE35904.1,
BAE26785.1,
BAE20450.1,
BAE42403.1,
BAE43282.1,
AAW82804.1,
AAI38695.1,
AAI38696.1
Ensembl_TRS:
ENSMUST00000042608
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000048180
RefSeq:
XP_011246737.1,
NP_001012656.1,
XP_006531238.1,
XP_006531232.1,
XP_006531233.1,
XP_030099521.1,
XP_006531237.1,
NP_001335278.1
|
| Others |
UniRef100:
UniRef100_Q5EE38
UniRef90:
UniRef90_Q5EE38
UniRef50:
UniRef50_Q5EE38
UniGene:
Mm.12964
CCDS:
CCDS22608.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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