WEE2 - WEE1 homolog 2-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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494551 WEE2

基因描述

Type	Description
Definition	WEE1 homolog 2

研究结论

Date	Results	Publications
2020-05-23 10:53:00	These findings confirmed our previous research and expanded the mutational spectrum of WEE2, making it a potential genetic diagnostic marker for those suffering from human fertilization failure.	30628060
2020-02-08 10:55:00	Novel compound heterozygous mutations c.598C>T (p.Arg200Ter) and c.1319G>C (p.Trp440Ser) in WEE2 gene in a female whose oocytes could not form pronucleus after intracytoplasmic sperm injection. Mutations in WEE2 gene affect the normal function of WEE2 proteins and cause fertilization failure.	31428887
2019-07-20 11:10:00	A high prevalence of WEE2 mutations was found in Chinese women experiencing fertilization failure or poor fertilization.	30827523
2019-07-20 11:10:00	Novel variants found in WEE2, which is autosomal-recessive inherited, may be related to recurrent pronucleus formation failure and female infertility.	30827524
2019-06-08 11:15:00	WEE2-AS1 over-expressed in HCC and was positively correlated to hepatitis B virus (HBV) infection, hepatic vascular invasion, poor tumor differentiation and poor patient prognosis. WEE2-AS1 also accelerated the proliferation, migration, invasion and cell cycle progression of HCC cells. A preliminary HBx-WEE2-AS1- FERMT3 pathway which may serve as a therapeutic target for HBV-associated HCC.	30471857

名称对应

Type	IDs
Synonymous	OOMD5, WEE1B
Gene	UniProtKB-ID: WEE2_HUMAN UniprotKB: P0C1S8 UniParc: UPI000004E9D3 EMBL: AC004918, AK131218 Ensembl: ENSG00000263042, ENSG00000214102 KO: hsa:494551
Nucleutide sequences	Ensembl_TRS: ENST00000574659, ENST00000397541
Protein sequencees	Ensembl_PRO: ENSP00000380675, ENSP00000459392 RefSeq: NP_001099028.1
Others	UniRef100: UniRef100_P0C1S8 UniRef90: UniRef90_P0C1S8 UniRef50: UniRef50_P0C1S8 UniGene: Hs.657927 CCDS: CCDS43660.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
31428887	Novel compound heterozygous mutations in WEE2 causes female infertility and fertilization failure. J Assist Reprod Genet Xiaopei Zhou , Lixia Zhu , Meiqi Hou , Yanling Wu , Zhou Li , Jiarui Wang , Zhenxing Liu , Dazhi Zhang , Lei Jin , Xianqin Zhang	2019-09-01	-
30628060	Novel mutations in WEE2: Expanding the spectrum of mutations responsible for human fertilization failure. Clin Genet Zhihua Zhang , Jian Mu , Junli Zhao , Zhou Zhou , Biaobang Chen , Ling Wu , Zheng Yan , Wenjing Wang , Lin Zhao , Jie Dong , Xiaoxi Sun , Yanping Kuang , Bin Li , Lei Wang , Qing Sang	2019-04-01	-
30827523	New biallelic mutations in WEE2: expanding the spectrum of mutations that cause fertilization failure or poor fertilization. Fertil Steril Jing Dai , Wei Zheng , Can Dai , Jing Guo , Changfu Lu , Fei Gong , Yan Li , Qinwei Zhou , Guangxiu Lu , Ge Lin	2019-03-01	-
30827524	Novel WEE2 gene variants identified in patients with fertilization failure and female infertility. Fertil Steril Shuai Zhao , Tailai Chen , Mengru Yu , Yuehong Bian , Yongzhi Cao , Yunna Ning , Shizhen Su , Jiangtao Zhang , Shigang Zhao	2019-03-01	-
30471857	Hepatitis B virus X protein related lncRNA WEE2-AS1 promotes hepatocellular carcinoma proliferation and invasion. Biochem Biophys Res Commun Zhigang Hu , Pinbo Huang , Yongcong Yan , Zhenyu Zhou , Jie Wang , Gang Wu	2019-01-01	-
29606300	Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility. Am J Hum Genet Qing Sang , Bin Li , Yanping Kuang , Xueqian Wang , Zhihua Zhang , Biaobang Chen , Ling Wu , Qifeng Lyu , Yonglun Fu , Zheng Yan , Xiaoyan Mao , Yao Xu , Jian Mu , Qiaoli Li , Li Jin , Lin He , Lei Wang	2018-04-05	-
28792760	Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J Med Chem Jin-Yi Zhu , Rebecca A Cuellar , Norbert Berndt , Hee Eun Lee , Sanne H Olesen , Mathew P Martin , Jeffrey T Jensen , Gunda I Georg , Ernst SchÃ¶nbrunn	2017-09-28	-
23568457	Genetic variants associated with disordered eating. Int J Eat Disord Tracey D Wade , Scott Gordon , Sarah Medland , Cynthia M Bulik , Andrew C Heath , Grant W Montgomery , Nicholas G Martin	2013-09-01	SH2D3C, C8orf37-AS1, TSHZ1, OLIG2, ZER1, PHTF1, OR9A4, SGPP2, ADH7, C4orf36, CHODL, MACROD2, TEKT5, DAB1, CNBD1, DNASE1L3, EMP2, ATOH7, FLG, FLNB, CLEC5A, MAGI3, CCDC69, GM2A, LOC284395, NKAIN3, GRID1, PKN3, FLG-AS1, GADL1, VSTM2B, HSD17B13, CATSPER3, FLG2, AFF1, MSRA, NCL, WEE2, CRNN, TAS2R3, TAS2R4, HSD17B11, PDE6D, PDE8A, WWOX, ATP8A2, PITX1, TAS2R5, CDV3, PRM1, PRM2, TMPRSS15, CAMK1D, TAS2R38, KLHL8, PTMA, QSOX1, PRM3, RASGRF2, ROBO2, CCL20, PERP, SET, CSMD1, SMTN, SSBP1, TNP2, MCTP1, SPHKAP, TAS1R2, C10orf11, C4orf17, PCBD2, ZDHHC12, KCNK5, SOCS1, ALDH4A1, MGAM, WDR34, COL23A1, NT5C1B, SYTL5, CEP350
23616086	Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos. Mol Med Rep Chao Liu , Yanchun Liu , Yang Liu , Didi Wu , Zhidong Luan , Enhua Wang , Bingzhi Yu	2013-06-01	Wee2
22623531	Functional genomics identifies therapeutic targets for MYC-driven cancer. Proc. Natl. Acad. Sci. U.S.A. Masafumi Toyoshima , Heather L Howie , Maki Imakura , Ryan M Walsh , James E Annis , Aaron N Chang , Jason Frazier , B Nelson Chau , Andrey Loboda , Peter S Linsley , Michele A Cleary , Julie R Park , Carla Grandori	2012-06-12	CDH5, NR1H3, CDK2, TRIB1, SPEG, ARFGEF2, SLC25A26, C17orf49, CPS1, MYO3B, CSNK1E, CTPS1, CTSD, GRK3, DDB2, EFNA5, ALDOA, SNRNP200, BRD4, PES1, FBXO5, GLI1, CECR2, GNRHR, GTF2H4, SH3KBP1, HCK, CXXC1, HPS1, HSD17B4, ICT1, IGF2R, FAM131C, ITGB5, LIMK2, MATK, MCL1, MYC, MYCN, MYLK, NEK2, NQO2, NTRK1, WEE2, PCBD1, ATP5D, REV1, PDK1, CDK12, PI4KB, POLA1, POLH, POLR2E, POLR2I, HAUS7, PKN1, PBK, SULF2, MAP2K3, MAP2K7, PAK6, PSMC2, CAMK1G, SCYL1, PTPN9, RAD21, RASGRF1, GRK1, SDC4, NECAB3, SLC1A4, WNK1, BMPR1A, BNIP2, BOK, SULT1A2, SUV39H1, BTK, TIE1, TXK, UBE2I, WEE1, YES1, CENPO, HECTD3, NEIL1, ALPK1, RASSF7, PTP4A2, CAMK2D, CAMK2G, KIF18A, TRRAP, GSG2, AIFM2, IRS2, CRADD, CCNK, PRC1

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