| Type | Description |
|---|---|
| Definition | toxin B |
| Date | Results | Publications |
|---|---|---|
| 2020-02-22 11:10:00 | A 3.87-A-resolution crystal structure of TcdB holotoxin captures a unique conformation of TcdB at endosomal pH. The C-terminal combined repetitive oligopeptides (CROPs) domain of TcdB is dynamic and can sample open and closed conformations. 3 crystal structures of TcdB-antibody complexes that reveal how antibodies could specifically inhibit the activities of individual TcdB domains. | 31308519 |
| 2019-05-18 10:30:00 | These data demonstrate that RstA is a transcriptional repressor that autoregulates its own expression and directly inhibits transcription of the TcdA and the TcdB toxin genes and two positive toxin regulators, thereby acting at multiple regulatory points to control toxin production. | 30862746 |
| 2018-12-01 11:01:00 | Cell-penetrating peptides derived from Clostridium difficile TcdB2 and a related large clostridial toxin. | 29247010 |
| 2018-03-10 11:58:00 | determined five different structures of the TcdA and TcdB glucosyltransferase domains and made use of a non-hydrolyzable UDP-glucose substrate | 28433497 |
| 2017-10-28 10:49:00 | In addition to establishing the binding region for CSPG4, this work ascribes for the first time a role in TcdB CROPs in receptor binding and further clarifies the relative roles of host receptors in TcdB pathogenesis. | 28842504 |
| Type | IDs |
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